Enhanced spontaneous antibody response after coronary artery bypass surgery

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
M SaloJ Ilonen

Abstract

Cells spontaneously secreting immunoglobulins can be seen in the blood one week after open-heart surgery. The purpose of this study was to measure the antibody specificities of activated cells. Immune responses were studied preoperatively and on the seventh postoperative day in 18 patients undergoing elective coronary artery bypass surgery. The number of cells secreting adenovirus, measles, rubella and tetanus antigen specific antibodies spontaneously and induced by pokeweed mitogen PWM (ASCs) as well as the total number of cells secreting IgG, IgM and IgA (ISCs) were studied using an enzyme-linked immunospot (ELISPOT) assay. Spontaneous as well as phytohaemagglutinin (PHA)- and pokeweed mitogen (PWM)-induced lymphocyte proliferation was also measured. The number of cells spontaneously secreting IgG, IgM and IgA antibodies was increased on the seventh day after coronary bypass surgery, against adenovirus, measles, rubella and tetanus as well as the total number of cells secreting immunoglobulins IgG, IgM and IgA (P < 0.05/0.001). By contrast, only slight fluctuation was seen in the numbers of cells secreting antibodies after PWM stimulation. Spontaneous lymphocyte proliferation was also increased, PHA proliferative responses we...Continue Reading

References

Jan 1, 1975·Immunological Communications·J EskolaO Ruuskanen
Feb 1, 1992·Lupus·N A Granholm, T Cavallo
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
Jun 1, 1987·The Journal of Experimental Medicine·D M Klinman, A D Steinberg
Jun 26, 1987·Journal of Chromatography·M Waris, P Halonen
Dec 16, 1983·Journal of Immunological Methods·C C CzerkinskyA Tarkowski
Jun 1, 1993·Immunology Today·F Powrie, R L Coffman
Feb 1, 1993·The Annals of Thoracic Surgery·J ButlerS Westaby
Dec 1, 1995·Journal of Medical Virology·M J MäkeläH Arvilommi
Jul 1, 1996·British Journal of Anaesthesia·P Sheeran, G M Hall

❮ Previous
Next ❯

Citations

Jan 16, 2002·International Immunopharmacology·N R PuigG Elena
Dec 12, 2001·Acta Anaesthesiologica Scandinavica·M SaloG C Moudgil
Feb 23, 2021·Journal of Immunotoxicology·Ashraf Mahmoud EmaraRehab Mohamed Elgharabawy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.