Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease

Journal of Neurophysiology
Lijun LiLynn A Raymond

Abstract

Huntington disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine tract near the N terminus of the protein huntingtin, leading to dramatic loss of striatal medium-sized spiny GABAergic projection neurons (MSNs). Evidence suggests overactivation of N-methyl-D-aspartate (NMDA)-type glutamate receptors (NMDARs) contributes to selective degeneration of MSNs in HD. Striatal MSNs are enriched in NR2B, and whole cell current and excitotoxicity mediated predominantly by the NR2B subtype of NMDARs is increased with expression of mutant huntingtin in transfected cell lines and striatal MSNs from mice models. To test whether synaptic NMDAR current is altered by mutant huntingtin expression, we recorded striatal MSN excitatory postsynaptic currents (EPSCs) evoked by stimulation of cortical afferents in corticostriatal slices from YAC72 mice and their wild-type (WT) littermates at age 21-31 days. The ratio of NMDAR- to AMPAR-mediated EPSC amplitude was significantly increased in YAC72 compared to WT mice. Furthermore, using a paired-pulse stimulation protocol as a measure of presynaptic glutamate release probability, we found no significant differences between YAC72 and WT striatal MSN responses. These...Continue Reading

References

May 28, 1992·The New England Journal of Medicine·J D RothsteinR W Kuncl
Jul 1, 1990·Trends in Neurosciences·M DiFiglia
Jul 1, 1990·Annals of Neurology·J D RothsteinJ T Coyle
Jan 1, 1989·Annual Review of Neuroscience·R S Zucker
Oct 1, 1988·Annals of Neurology·C K ParkJ McCulloch
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·J P VonsattelE P Richardson
Nov 7, 1987·British Dental Journal·M J WilliamsK C Ashley
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Oct 6, 1997·Journal of Neurophysiology·M Umemiya, L A Raymond
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·J C BrimecombeE Aizenman
May 22, 1998·Journal of Neuropathology and Experimental Neurology·J P Vonsattel, M DiFiglia
Apr 27, 1999·Journal of Neurochemistry·N ChenL A Raymond
Mar 11, 2000·Journal of Neurophysiology·G RumbaughS Vicini
Apr 1, 2000·The Journal of Comparative Neurology·K D KüppenbenderG B Landwehrmeyer
Aug 15, 2000·Trends in Neurosciences·J H Cha
Aug 23, 2000·Molecular Pharmacology·S D Donevan, R T McCabe
Jan 12, 2001·Journal of Neurophysiology·I Joshi, R D Andrew
Feb 13, 2001·Molecular and Cellular Neurosciences·M M ZeronL A Raymond
Dec 18, 2001·Journal of Neuroscience Research·C CepedaM S Levine
Jun 29, 2002·Nature Neuroscience·Alexander V PanovJ Timothy Greenamyre
Aug 6, 2002·Neuron·Andres Barria, Roberto Malinow
Jan 11, 2003·Journal of Neurophysiology·David E ChapmanKaren S Wilcox
Apr 4, 2003·The International Journal of Biochemistry & Cell Biology·Geoffrey M Goellner, Martin Rechsteiner
Apr 30, 2003·Journal of Neurochemistry·Anthone W Dunah, David G Standaert
Dec 4, 2003·Neurobiology of Aging·Lijun LiLynn A Raymond

❮ Previous
Next ❯

Citations

Apr 8, 2009·Cellular and Molecular Neurobiology·Edén Flores-BarreraElvira Galarraga
May 11, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jianming YangHuangui Xiong
Sep 8, 2012·Molecular Neurobiology·Maciej FigielWlodzimierz J Krzyzosiak
Feb 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Huai-Xing Wang, Wen-Jun Gao
Sep 7, 2011·Nature Reviews. Neurology·Joanna M Karasinska, Michael R Hayden
Jan 19, 2011·Clinical Neuropharmacology·Hiroshi Kataoka, Satoshi Ueno
Nov 12, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rona K GrahamMichael R Hayden
Feb 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rona K GrahamMichael R Hayden
Feb 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Prasad R JoshiNigel S Bamford
May 5, 2010·The Journal of Cell Biology·Yasushi EnokidoHitoshi Okazawa
Jan 6, 2012·Neurología : publicación oficial de la Sociedad Española de Neurología·M E Flores-SotoC Beas-Zarate
May 24, 2011·Molecular and Cellular Neurosciences·Clare M Gladding, Lynn A Raymond
Jul 5, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jie FanTing Li
Mar 14, 2007·European Journal of Pharmacology·Svenja Esther Sander, Angelika Richter
Jul 11, 2006·Trends in Biochemical Sciences·James F Gusella, Marcy E MacDonald
Apr 14, 2016·Neurobiology of Disease·Kashif MahfoozJohn F Wesseling
Apr 23, 2013·Trends in Neurosciences·Sarah R HulmeWickliffe C Abraham
Dec 15, 2010·Biochimica Et Biophysica Acta·Catarina V GomesRodrigo A Cunha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.