Enhanced sucrose and Polycose preference in sweet "sensitive" (C57BL/6J) and "subsensitive" (129P3/J) mice after experience with these saccharides

Physiology & Behavior
A Sclafani

Abstract

Prior research with inbred mouse strains indicates that C57BL/6J (B6) mice display stronger preference and acceptance for various sweeteners than do 129P3/J (129) mice. Experiment 1 examined the extent to which this strain difference could be modified by repeated exposure to sucrose. Sucrose-naive 129 mice displayed weaker preferences than did B6 mice for 0.5% to 4% sucrose solutions during 23h/day sugar vs. water tests. Sucrose preference did not differ at 8-32% concentrations. Yet, when retested with sucrose, the 129 and B6 mice showed identical robust preferences (>90%) for 0.5-32% solutions. The strains also did not differ in sucrose preference in tests with descending sucrose concentrations (0.5-0.0625%). Sucrose-experienced 129 mice also showed enhanced preference for dilute saccharin solutions suggesting that their sweet taste responsivity was enhanced. Experiment 2 revealed that preference for dilute saccharin solutions was enhanced by prior saccharin experience in B6 but not 129 mice. Experiment 3 tested the strains with Polycose which has a palatable taste different from that of sucrose. Polycose-naive 129 mice displayed weaker preferences for dilute (0.5-4%) but not concentrated (8-32%) Polycose solutions relative to...Continue Reading

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Citations

Mar 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Steven L Youngentob, John I Glendinning
Apr 3, 2013·Chemical Senses·Steven ZukermanAnthony Sclafani
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Dec 19, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Steven ZukermanAnthony Sclafani
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Jul 6, 2010·Physiology & Behavior·John I GlendinningAnthony Sclafani

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