Enhanced survival of Drosophila Akt1 hypomorphs during amino-acid starvation requires foxo

Genome Génome / Conseil National De Recherches Canada
Jennifer D Slade, Brian E Staveley

Abstract

Disordered eating includes any pattern of irregular eating that may lead to either extreme weight loss or obesity. The conserved insulin receptor signalling pathway acts to regulate energy balance and nutrient intake, and its central component Akt1 and endpoint effector foxo are pivotal for survival during nutritional stress. Recently generated Akt1 hypomorphic mutant lines exhibit a moderate decrease in lifespan when aged upon standard media, yet show a considerable increase in survival upon amino-acid starvation media. While the loss of foxo function significantly reduces the survival response to amino-acid starvation, a combination of these Akt1 hypomorphs and a null foxo mutation reveal a synergystic and severe reduction in lifespan upon standard media, and an epistatic relationship when undergoing amino-acid starvation. Evaluation of survivorship upon amino-acid starvation media of these double mutants indicate a phenotype similar to the original foxo mutant demonstrating the role of foxo in this Akt1 phenotype. These results indicate that the subtle manipulation of foxo through Akt1 can enhance survival during adverse nutrient conditions to model the ability of individuals to tolerate nutrient deprivation. Ultimately, we ...Continue Reading

References

Mar 15, 1997·Genes & Development·S G KennedyN Hay
May 28, 1998·Current Biology : CB·B E StaveleyA S Manoukian
Nov 13, 1998·Current Opinion in Neurobiology·G Nuñez, L del Peso
Dec 10, 1999·Nature Cell Biology·J VerduM J Birnbaum
Jun 9, 2001·Cell and Tissue Research·C Cao, M R Brown
Jun 22, 2001·The Psychiatric Clinics of North America·S Nielsen
Aug 24, 2001·Archives of Insect Biochemistry and Physiology·J V Broeck
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·M P Scheid, J R Woodgett
Jul 13, 2002·Trends in Biochemical Sciences·Boudewijn M T Burgering, Geert J P L Kops
Feb 8, 2003·Lancet·Christopher G Fairburn, Paul J Harrison
May 30, 2003·Journal of Leukocyte Biology·Boudewijn M T Burgering, René H Medema
Jul 8, 2003·BMC Developmental Biology·Jamie M KramerBrian E Staveley
Dec 10, 2003·Oncogene·Thomas F FrankeChizuru Sugimoto
Dec 8, 2004·Experimental Gerontology·Marc Tatar
Feb 16, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Valeria CavaliereGiuseppe Gargiulo
Feb 24, 2005·Psychological Medicine·Manfred M Fichter, Norbert Quadflieg
Apr 30, 2005·Trends in Endocrinology and Metabolism : TEM·Andreas BarthelTerry G Unterman
Oct 19, 2005·Genes & Development·Oscar Puig, Robert Tjian
Feb 1, 1938·Proceedings of the National Academy of Sciences of the United States of America·G W BeadleJ Maxwell
Apr 18, 2006·Mechanisms of Ageing and Development·Kyung-Jin Min, Marc Tatar
Aug 24, 2007·Journal of Evolutionary Biology·S Rion, T J Kawecki
Jul 25, 2008·Genome Génome / Conseil National De Recherches Canada·Jamie M KramerBrian E Staveley
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hua ZhangLeslie Pick
Apr 19, 2015·BMC Research Notes·Jennifer D Slade, Brian E Staveley

❮ Previous
Next ❯

Citations

Apr 15, 2016·Genome Génome / Conseil National De Recherches Canada·Jennifer D Slade, Brian E Staveley

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Related Papers

BMC Research Notes
Jennifer D Slade, Brian E Staveley
Genome Génome / Conseil National De Recherches Canada
Jamie M KramerBrian E Staveley
© 2022 Meta ULC. All rights reserved