PMID: 7993156Dec 12, 1994Paper

Enhanced susceptibility to amiodarone-induced hypothyroidism in patients with thyroid autoimmune disease

Archives of Internal Medicine
E MartinoL Braverman

Abstract

The iodine-rich antiarrhythmic drug, amiodarone, can induce both thyrotoxicosis and hypothyroidism, the former being more frequent in iodine-deficient areas, the latter in iodine-sufficient areas. In this study we evaluated prospectively thyroid function in amiodarone-treated patients with positive or negative baseline thyroid autoantibody test results who resided in a moderately iodine-deficient area of Italy. Two groups of patients received long-term amiodarone treatment: Group 1 included 13 patients with negative thyroid autoantibody test results. Group 2 consisted of seven patients with positive thyroid autoantibody test results and thyroid ultrasound patterns compatible with Hashimoto's thyroiditis. The control group (group 3) included 16 untreated euthyroid patients with Hashimoto's thyroiditis. All subjects resided in a mildly iodine-deficient area of Italy (Southern Sardinia) and had low urinary iodine values. Patients in groups 1 and 2 had markedly elevated urinary iodine excretion during treatment. The follow-up period ranged from 6 to 29 months in group 1, from 4 to 9 months in group 2, and from 12 to 55 months in group 3. Two (15%) of 13 patients in group 1 with nodular goiter developed thyrotoxicosis. No patient in...Continue Reading

Citations

Dec 17, 1998·Journal of Endocrinological Investigation·S GrossoG Morgese
Mar 27, 2001·Journal of Endocrinological Investigation·L BartalenaE Martino
Feb 12, 2014·International Journal of Clinical Pharmacy·Chun-Jui HuangLiang-Yu Lin
Jun 18, 2014·European Journal of Endocrinology·Luca TomistiFausto Bogazzi
Apr 22, 2005·Reviews in Endocrine & Metabolic Disorders·Mouhammed Habra, Nicholas J Sarlis
Feb 21, 2008·Wiener medizinische Wochenschrift·Peter Mikosch
May 25, 2013·Endocrinology and Metabolism Clinics of North America·W Edward VisserRobin P Peeters
Jul 2, 2005·The American Journal of Medicine·Shehzad Basaria, David S Cooper
Aug 4, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A Pazin-FilhoL M Z Maciel
Mar 18, 2006·Arquivos brasileiros de endocrinologia e metabologia·Beatriz D SchaanMiguel Gus
Feb 25, 1998·Pacing and Clinical Electrophysiology : PACE·M Jafari-Fesharaki, M M Scheinman
Apr 8, 2004·Thyroid : Official Journal of the American Thyroid Association·Laura E RyanRichard T Kloos
Aug 1, 1997·Thyroid : Official Journal of the American Thyroid Association·F BogazziE Martino
Aug 30, 2007·Thyroid : Official Journal of the American Thyroid Association·Labrini PapanastasiouGeorge Mastorakos
Jun 9, 2001·Thyroid : Official Journal of the American Thyroid Association·F BogazziE Martino
Jun 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Joyce R SilvaLaura S Ward
Jul 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Irene KaloumenouCatherine Dacou-Voutetakis
May 22, 2010·International Journal of Clinical Practice·C J TaylorF D R Hobbs
Oct 20, 2005·Clinical and Experimental Immunology·J G BarinC L Burek
Apr 11, 2001·Endocrine Reviews·E MartinoL E Braverman
Mar 1, 2008·Expert Review of Clinical Immunology·Nobuyuki Takasu, Jaeduk Yoshimura Noh
Jul 24, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Angela M Leung, Lewis E Braverman
Aug 11, 2019·Journal of Clinical Pharmacy and Therapeutics·Sayoko KinoshitaMitsutaka Takada
Jul 1, 2010·Expert Review of Endocrinology & Metabolism·Angela LeungLewis E Braverman
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·G KahalyG Hommel
Oct 23, 2008·The Journal of Clinical Endocrinology and Metabolism·Kai-Hang YiuWing-Hing Chow
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Fausto BogazziEnio Martino
Aug 11, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Poorani N Goundan, Stephanie L Lee
May 18, 2013·Arquivos brasileiros de endocrinologia e metabologia·Gisah Amaral de CarvalhoLaura Sterian Ward
Dec 7, 2016·Journal of Arrhythmia·Sayoko KinoshitaMitsutaka Takada
Aug 7, 2010·Southern Medical Journal·Hema Padmanabhan
Jan 14, 2017·European Journal of Clinical Pharmacology·Mikie YamatoMitsutaka Takada
Jun 27, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Mervat M El-Eshmawy, Maha Shahin
Dec 22, 2004·Arquivos brasileiros de endocrinologia e metabologia·Renata PavanLéa M Z Maciel
Oct 2, 2007·The American Journal of Medicine·Elizabeth L BatcherUNKNOWN SAFE-T Investigators

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