PMID: 2508150Jan 1, 1989Paper

Enhanced susceptibility to kindling by chlordimeform may be mediated by a local anesthetic action

Psychopharmacology
M E Gilbert, C M Mack

Abstract

The formamidine pesticides amitraz and chlordimeform have recently been shown to be potent proconvulsants (Gilbert 1988). Two main neuroactive properties have been identified as mediators of formamidine neurotoxicity, alpha-2 adrenergic agonism and local anesthetic actions. These two proposed mechanisms of formamidine action were contrasted using electrical kindling of the amygdala. Male rats were administered 0, 10 and 40 mg/kg of the local anesthetic lidocaine, 0, 0.01 and 0.10 mg/kg of the alpha-2 adrenergic agonist clonidine or 0, 10 and 30 mg/kg chlordimeform, IP, once per day. After each injection, kindling stimulation was delivered through chronically-implanted electrodes. The high dosage of chlordimeform and both dosages of lidocaine enhanced the rate of kindling development (mean sessions to stage 5 seizures = 8.6 +/- 1.16, 10.15 +/- 1.04 and 8.5 +/- 0.95, respectively) relative to controls (mean = 14.59 +/- 1.36). Afterdischarge (AD) durations were increased over the first seven sessions by both treatments, but the total cumulative AD did not differ from controls. Clonidine, by contrast, delayed kindling development (mean 27.57 +/- 1.97) and shortened the mean AD duration over the first seven sessions. These data prov...Continue Reading

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Citations

Mar 1, 1992·Neurotoxicology and Teratology·M E Gilbert
Jul 1, 1993·Neurotoxicology and Teratology·M E Gilbert, J Llorens
Mar 1, 1995·Neurotoxicology and Teratology·M E Gilbert, C M Mack
Oct 3, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Henricus G RuhéAart H Schene
Sep 5, 2001·The Australian and New Zealand Journal of Psychiatry·R BellD Copolov
Nov 17, 1994·The New England Journal of Medicine·L Gram
Oct 1, 1991·The Journal of General Psychology·J B Murray
May 15, 2015·Chemical Research in Toxicology·Javier del PinoMaría Teresa Frejo
Jan 14, 1998·Human & Experimental Toxicology·K AydinI K Hallaç
Dec 28, 2000·Human & Experimental Toxicology·A YaramisM Bilici
Oct 13, 2012·Human & Experimental Toxicology·Lh Hetherington, Jm Battershill
May 10, 2002·Annals of the New York Academy of Sciences·M E Gilbert
Jul 19, 2018·Neurotoxicology·Mar RequenaRaquel Alarcón

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