Enhanced syphilis screening among HIV-positive men (ESSAHM): a study protocol for a clinic-randomized trial with stepped wedge design

Implementation Science : IS
Ann N BurchellDarrell H S Tan

Abstract

The current syphilis epidemic among urban men who have sex with men (MSM) has serious implications for those co-infected with human immunodeficiency virus (HIV). Routine and frequent syphilis screening has the potential to ensure early detection and treatment, minimize disease burden, and help control the ongoing spread of syphilis and HIV. We aim to enhance syphilis screening among HIV-positive men by conducting a clinic-based intervention that incorporates opt-out syphilis testing into routine HIV laboratory evaluation for this population. Trial objectives are to determine the degree to which the intervention (1) increases the detection rate of untreated syphilis, (2) increases screening coverage, (3) increases screening frequency, and (4) reaches men at highest risk according to sexual behaviors. The trial is a pragmatic, stepped wedge cluster-randomized controlled trial that introduces the intervention stepwise across four urban HIV clinics in Ontario, Canada. The intervention includes standing orders for syphilis serological testing whenever a male in HIV care undergoes HIV viral load testing, which typically occurs every 3-6 months. The control condition is the maintenance of current, provider-initiated syphilis testing p...Continue Reading

References

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May 29, 2013·BMC Infectious Diseases·Ann N BurchellUNKNOWN OHTN Cohort Study Research Team
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Aug 21, 2015·BMC Infectious Diseases·Ann N BurchellUNKNOWN OHTN Cohort Study Team

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Citations

Dec 6, 2018·Revista Da Sociedade Brasileira De Medicina Tropical·Alex Maurício Garcia SantosPaulo Sérgio Ramos de Araújo
Jun 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ann N BurchellVanessa G Allen

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Clinical Trials Mentioned

NCT02019043

Software Mentioned

ESSAHM
Access
SAS

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