Enhanced template activity in chromatin from adrenal medulla after phosphorylation of chromosomal proteins

D M ChuangE Costa


Translocation of protein kinase to the nucleus had been implicated earlier in the transsynaptic control of gene expression mediated by cholinergic nerves in adrenal medulla. Phosphorylation of chromosomal proteins by adenosine 3',5'-monophosphate-dependent protein kinase and adenosine 3',5'-monophosphate enhances the template activity of chromatin from adrenal medulla. When homologous RNA polymerase II is used the relative activation is greater than that obtained with Escherichia coli RNA polymerase. The substrate for such phosphorylation does not seem to be RNA polymerase II. Phosphorylation of specific acidic protein probably mediates this enhancement of template activity.


Jan 1, 1982·Progress in Neurobiology·P A KometianiE E Klein
Jan 1, 1978·Neuroscience·J P Schwartz, E Costa
May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·K E WintersW Lovenberg
Nov 14, 1978·Biochemical and Biophysical Research Communications·K R Huff, G Guroff
Apr 25, 1977·Biochemical and Biophysical Research Communications·V L Dunham, W N Yunghans
Jan 7, 1983·Journal of Theoretical Biology·F J Conway

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