PMID: 7518275Jan 1, 1994Paper

Enhanced tenascin immunoreactivity in leukoplakia and squamous cell carcinoma of the oral cavity: an immunohistochemical study

European Journal of Cancer. Part B, Oral Oncology
P ShresthaM Mori

Abstract

Tenascin is an extracellular matrix glycoprotein that shows a site restricted expression especially in areas of cell proliferation, cell motility, and tissue modeling at the epithelial-mesenchymal junction during embryogenesis. Tissue specimens obtained from surgery and/or biopsy for oral leukoplakia (n = 22) and squamous cells carcinoma (n = 36) were examined for the presence of tenascin by using monoclonal antibody. In normal tissue specimens (n = 5), tenascin immunoreaction appeared as a linear continuous lining at the immediate vicinity of basement membrane (n = 3). Hyperplastic epithelia in leuoplakia showed a distinct increase in tenascin immunoreactivity in the submucosa correlating with the degree of hyperplasis and/or dysplasia. In squamous cell carcinoma (SCC), the reactivity was most intense extending deeply into the underlying stroma with marked reaction around large tumour cell nests and the infiltrating tumour margin. The connective tissue stroma, however, in undifferentiated carcinoma showed traces of immunoreactivity. Positive immunoreactivity was seen around metastatic squamous cell carcinoma masses in regional lymph nodes. The stromal tissues infiltrated by inflammatory cells were usually unreactive while thos...Continue Reading

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Citations

Sep 4, 2010·Cancer Metastasis Reviews·David S GutteryRosemary A Walker
May 1, 1995·European Journal of Cancer. Part B, Oral Oncology·S K LeeM Mori
Jul 1, 1995·European Journal of Cancer. Part B, Oral Oncology·M MoriP Shrestha
Mar 1, 1996·European Journal of Cancer. Part B, Oral Oncology·P ShresthaM Mori
Dec 5, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Joseph A RegeziRichard C K Jordan
Apr 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A J MighellW J Hume
Apr 4, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·D R ManeS Hallikerimath
Mar 21, 2015·Cell Adhesion & Migration·Alexander BerndtMarcus Franz
Nov 22, 2017·Journal of Cellular and Molecular Medicine·Takayoshi SumiokaShizuya Saika
Dec 5, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takayoshi SumiokaShizuya Saika
Mar 11, 2010·The Journal of Small Animal Practice·E KulendraD Brockman
Oct 24, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Ulf MattssonPalle Holmstrup

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