Enhanced TGFalpha-EGFR expression and P53 gene alterations contributes to gastric tumors aggressiveness

Cancer Letters
Luis A EspinozaGustavo Ballejo

Abstract

We determined whether alterations in the expression of p53, p16(INK4) and p21(WAF1/CIP1) influence the invasiveness of a subset of gastric adenocarcinomas co-expressing TGFalpha and EGFR. Immunopositivity for TGFalpha-EGFR (26%) was observed in both early and advanced adenocarcinomas, and 88% of these showed immunoreactivity for p53. SSCP analysis revealed that in 81% of these tumors the p53 gene was mutated in exons 5-8. The intensity of p53 immunoreactivity was significantly higher (P < 0.013) in deeply invasive tumors. p16(INK4) and p21(WAF1/CIP1) immunoreactivity was detected in 93 and 76% of the samples co-expressing TGFalpha-EGFR but the levels were not correlated with those of p53 and other clinico-pathological parameters. We conclude that gastric adenocarcinomas potentially dependent upon the TGFalpha-EGFR autocrine loop for growing exhibit increased aggressiveness in the presence of aberrant p53.

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Citations

May 13, 2006·American Journal of Respiratory Cell and Molecular Biology·Luis A EspinozaMark E Smulson
Nov 19, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Juan WuRuiping Wang
Dec 10, 2016·Journal of Cancer Research and Clinical Oncology·Julia KneisslBirgit Luber
May 31, 2006·World Journal of Gastroenterology : WJG·J C BeckerT Pohle
Feb 19, 2008·Experimental and Molecular Pathology·I UberallM Hajdúch

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