Enhanced therapeutic effects on the multi-drug resistant human leukemia cells in vitro and xenograft in mice using the stealthy liposomal vincristine plus quinacrine

Fundamental & Clinical Pharmacology
Gong-Wen LiangQiang Zhang

Abstract

The multi-drug resistance (MDR) could be caused by the over-expression of adenosine triphosphate binding cassette transporters such as p-glycoprotein, thereby resulting in the efflux of anti-cancer drugs from the cells. An anti-resistant stealthy liposomal vincristine plus quinacrine was defined in this study. Human chronic myelogenous leukemia K562 and MDR K562 cells were included for comparisons. Anti-tumor activity studies were performed on female BALB/c nude mice with MDR K562 cell xenografts. Results showed that quinacrine was effective in reversing the resistance in the MDR K562 cells, and enhanced the anti-tumor effect of vincristine in K562 cells. The caspase-9 and -3 activities in the MDR K562 and K562 cells were increased with the dose rise of quinacrine. In the MDR K562 cell xenografts in mice, the anti-resistant tumor effect of the stealthy liposomal vincristine plus quinacrine was evidently observed. The enhanced anti-tumor effects of vincristine by quinacrine in the resistant/non-resistant K562 cells could be because of the direct injury and the potentiating apoptotic effect of vincristine via activating the initiator caspase-9 and subsequently the effector caspase-3, and the long circulatory effect of stealthy li...Continue Reading

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Citations

Dec 26, 2015·Mitochondrion·Bing YanJiri Neuzil
Jan 31, 2012·Biochemical Pharmacology·Che-Ming Jack Hu, Liangfang Zhang
Oct 26, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ruo-Jing LiWan-Liang Lu
Oct 28, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Xiao-Li SongXue-Tao Li
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Sep 29, 2019·Seminars in Cancer Biology·Derek B OienViji Shridhar
Jul 24, 2020·Anti-cancer Agents in Medicinal Chemistry·Biswajit Das, Chanakya N Kundu

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