Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron

Journal of Psychopharmacology
G E JacobsJ M A van Gerven

Abstract

A recently developed oral serotonergic challenge test consisting of 5-Hydroxytryptophane (5-HTP, 200 mg) combined with carbidopa (CBD, 100 mg + 50 mg) exhibited dose-related neuroendocrine responsiveness and predictable pharmacokinetics. However, its applicability is limited by nausea and vomiting. A randomized, double-blind, placebo-controlled, four-way crossover trial was performed in 12 healthy male volunteers. The 5-HTP/CBD-challenge was combined with two oral anti-emetics (granisetron, 2 mg or domperidone, 10 mg) to investigate its reliability when side-effects are suppressed. The neuroendocrine response (serum cortisol and prolactin), the side-effect profile [Visual Analogue Scale Nausea (VAS)] and vomiting subjects per treatment were the main outcome measures. Compared to 5-HTP/CBD/placebo, 5-HTP/CBD/ granisetron had no impact on cortisol [% change with 95% confidence interval: -7.1% (18.9; 6.5)] or prolactin levels [-9.6% (-25.1; 9.1)]; 5-HTP/CBD/domperidone increased cortisol [+13.0% (-4.2; 33.4)], and increased prolactin extensively [+336.8% (245.7; 451.9)]. Compared to placebo, VAS Nausea increased non-significantly with granisetron [+7.6 mm (-1.3; 16.5)], as opposed to domperidone [+16.2 mm (7.2; 25.2)] and 5-HTP/CB...Continue Reading

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Citations

Jul 31, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hiam Abdala-ValenciaJoan M Cook-Mills
Jul 27, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·G E JacobsJ M A van Gerven
Feb 9, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·G E JacobsJ M A van Gerven
Aug 19, 2015·NeuroImage·Bernadet L KlaassensJoop M A van Gerven
Sep 14, 2016·Human Brain Mapping·Bernadet L KlaassensJoop M A van Gerven

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