Enhanced transmembrane proton conductance in Streptococcus mutans GS-5 due to ionophores and fluoride.

Antimicrobial Agents and Chemotherapy
A D Eisenberg, R E Marquis

Abstract

The uptake of protons by intact cells of Streptococcus mutans GS-5 was measured directly by assessing the pH increase in lightly buffered cell suspensions as protons moved across the plasma membrane after acid pulses. The barrier function of the cell membrane for protons was disrupted completely by 5% (vol/vol) butanol. This function was compromised severely by the ionophores valinomycin and gramicidin and by the uncoupler carbonylcyanide-m-chlorophenyl hydrazone. Proton conduction across the membrane was also enhanced by fluoride. It appeared that HF traversed the membrane and acted as a carrier. Once in the relatively alkaline cytoplasm, HF dissociated to yield F- and H+, which acted to acidify the cytoplasm and reduced the pH difference across the membrane.

References

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Jul 1, 1980·Journal of Dental Research·A D Eisenberg, R E Marquis

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Citations

May 1, 1984·Calcified Tissue International·G M Whitford, D H Pashley
Feb 15, 2003·FEMS Microbiology Reviews·Robert E MarquisMarilaine Mota-Meira
Oct 1, 1991·Oral Microbiology and Immunology·C Van LoverenJ M Ten Cate
Feb 1, 1988·International Journal of Cardiology·L O HughesE B Raftery
Dec 1, 1982·Journal of Applied Toxicology : JAT·G M WhitfordH S Wang
Sep 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A A ScheieG Rölla
Sep 24, 2008·Journal of Dental Research·M T Ashby
May 1, 1992·Journal of Dental Research·S G Dashper, E C Reynolds
Nov 1, 1983·Journal of Dental Research·E A Thibodeau, R E Marquis
Feb 1, 1985·Journal of Dental Research·G R BenderR E Marquis
Sep 1, 1984·Journal of Dental Research·D A Camosci, N Tinanoff
Nov 19, 2003·Oral Microbiology and Immunology·P K SreenivasanA Gaffar
Sep 1, 1987·Oral Microbiology and Immunology·K A Lau, T A Kral
Sep 1, 1995·Canadian Journal of Microbiology·W A BelliR E Marquis
Feb 6, 2020·Bioinformatics·Rostislav K SkitchenkoAlbert Guskov
Feb 16, 2019·Journal of Applied Microbiology·S KolbeckM A Ehrmann
Feb 1, 1990·Journal of Dental Research·G M Whitford
Apr 1, 1985·Infection and Immunity·S Kashket, E R Kashket
Jul 1, 1983·Infection and Immunity·W W YotisL Glendenin
Aug 1, 1986·Infection and Immunity·G R BenderR E Marquis
Aug 1, 1984·Infection and Immunity·J S van der Hoeven, H C Franken

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