Abstract
Conventional tumor starving therapy by reducing its vessel density may be effective at early treatment but potentially contributes to tumor hypoxia, drug resistance and metastasis. A new strategy through enhancing tumor angiogenesis in combination with effective chemotherapeutic drugs, has shown successful tumor growth and spread inhibition. To achieve in situ release of angiogenic and antitumor drugs in tumor, we designed a precise ratiometric polymeric hybrid micelle system for co-delivering nitric oxide and paclitaxel. The hybrid micelles could accumulate in tumor via the long blood circulation and enhanced permeability and retention (EPR) effect, promote the drug accumulation and penetration in tumor by in situ increased vascular permeability, blood perfusion and vessel density, achieve the synergistic antitumor effect of nitric oxide and paclitaxel through modified tumor microenvironment, overcome multidrug resistance and inhibit metastasis. This study presents a combinational therapy against tumor progression and spread, which shows great potential in cancer therapy of the future.
Citations
Dec 2, 2017·Drug Delivery·Shan-Shan QiShu-Qin Yu
Nov 29, 2017·Drug Delivery·Songwei TanQing Tang
Jan 20, 2018·Drug Delivery·Jinling WangPengfei Tu
Mar 12, 2019·Nanoscale·Yan XuXueming Li
May 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Guangping YuShengsong Tang
Jan 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ronghua NiYun Chen
Feb 26, 2019·Future Medicinal Chemistry·Qingbin CuiZhe-Sheng Chen
Apr 28, 2020·Current Medical Science·Yang GuanSong-Wei Tan
Sep 1, 2018·Pharmaceutical Research·Mengyuan ZhangJianping Liu
May 19, 2019·The AAPS Journal·Quoc-Viet LeYu-Kyoung Oh
Jan 14, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min SunRupei Tang
Jun 11, 2019·Frontiers in Pharmacology·Liu-Qing YangJian-Ge Zhang
Dec 15, 2020·Advanced Healthcare Materials·Guorui JinDan Ding
Jul 22, 2019·Cancer Letters·Rebeca Burgos-PanaderoRosa Noguera
Mar 12, 2021·Advanced Drug Delivery Reviews·Yanhong LiuTingjie Yin
Apr 10, 2021·Biomaterials·Yachao ZhangShuangying Gui
Jul 2, 2021·Nanotechnology·Md RizwanullahSaima Amin
Jun 8, 2018·ACS Applied Materials & Interfaces·Chuan HuHuile Gao
Feb 6, 2018·Molecular Pharmaceutics·Yan QiZhiping Zhang