Enhanced Vibrational Spectroscopies as Tools for Small Molecule Biosensing

Sensors
Souhir BoujdayWolfgang Knoll

Abstract

In this short summary we summarize some of the latest developments in vibrational spectroscopic tools applied for the sensing of (small) molecules and biomolecules in a label-free mode of operation. We first introduce various concepts for the enhancement of InfraRed spectroscopic techniques, including the principles of Attenuated Total Reflection InfraRed (ATR-IR), (phase-modulated) InfraRed Reflection Absorption Spectroscopy (IRRAS/PM-IRRAS), and Surface Enhanced Infrared Reflection Absorption Spectroscopy (SEIRAS). Particular attention is put on the use of novel nanostructured substrates that allow for the excitation of propagating and localized surface plasmon modes aimed at operating additional enhancement mechanisms. This is then be complemented by the description of the latest development in Surface- and Tip-Enhanced Raman Spectroscopies, again with an emphasis on the detection of small molecules or bioanalytes.

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Citations

Feb 13, 2016·Nanotechnology·Raymond GillibertMarc Lamy de la Chapelle
May 15, 2020·Nanomaterials·Wafa SafarMarc Lamy de la Chapelle

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Methods Mentioned

BETA
PCR
ELISA
Surface
biosensors
biosensing
Infrared Spectroscopy
Biosensor
chip
surface plasmon
Surface Enhanced Raman Scattering

Software Mentioned

MIT Electromagnetic Equation Propagation software
TERS

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