Enhanced XPA mRNA levels in cisplatin-resistant human ovarian cancer are not associated with XPA mutations or gene amplification

Cancer Letters
J C States, E Reed

Abstract

Enhanced expression of the nucleotide excision repair gene XPA is associated with resistance to cisplatin treatment in human ovarian cancer. Understanding the cause of enhanced XPA expression will provide new molecular targets for therapy directed at overcoming chemoresistance. Enhanced gene expression in cancer cells is often caused by mutations or gene amplification. Molecular analyses of the XPA genes in human ovarian cancers indicate that gene mutation and amplification are not the cause of enhanced XPA mRNA levels in ovarian cancers overexpressing XPA. Altered nucleotide excision repair (NER) gene regulation in chemoresistant tumors is discussed.

References

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Citations

Jun 12, 2010·Ear and Hearing·O'neil W Guthrie, Franklin A Carrero-Martínez
Sep 22, 2007·Gynecologic Oncology·J Salvador SaldivarDavid Gershenson
Mar 6, 2007·Critical Reviews in Oncology/hematology·David J Stewart
Jan 22, 2013·International Journal of Cancer. Journal International Du Cancer·Xicheng SongGuojun Li
Mar 21, 2002·Cancer Investigation·Sridhar ManiStephen G Chaney
Jun 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine S WalshBeth Y Karlan
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eddie Reed
Dec 26, 2001·Chemical Reviews·E R Jamieson, S J Lippard

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