Enhancement and suppression in a lexical interference fMRI-paradigm.

Brain and Behavior
Stefanie AbelWalter Huber

Abstract

Previous picture-word interference (PWI) fMRI-paradigms revealed ambiguous mechanisms underlying facilitation and inhibition in healthy subjects. Lexical distractors revealed increased (enhancement) or decreased (suppression) activation in language and monitoring/control areas. Performing a secondary examination and data analysis, we aimed to illuminate the relation between behavioral and neural interference effects comparing target-related distractors (REL) with unrelated distractors (UNREL). We hypothesized that interference involves both (A) suppression due to priming and (B) enhancement due to simultaneous distractor and target processing. Comparisons to UNREL should remain distractor unspecific even at a low threshold. (C) Distractor types with common characteristics should reveal overlapping brain areas. In a 3T MRI scanner, participants were asked to name pictures while auditory words were presented (stimulus onset asynchrony [SOA] = -200 msec). Associatively and phonologically related distractors speeded responses (facilitation), while categorically related distractors slowed them down (inhibition) compared to UNREL. As a result, (A) reduced brain activations indeed resembled previously reported patterns of neural primi...Continue Reading

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Citations

Feb 19, 2014·Brain and Language·Juliane MuehlhausKatharina Sass
Jul 13, 2014·Brain and Language·Anna OhElizabeth W Pang
Feb 18, 2015·Brain : a Journal of Neurology·Stefanie AbelKarsten Specht
Apr 10, 2014·Frontiers in Human Neuroscience·Michele T DiazC Christine Camblin
Aug 10, 2019·NeuroImage. Clinical·Michael S JacobDaniel H Mathalon
Jul 24, 2021·Cerebral Cortex Communications·Elin RunnqvistF-Xavier Alario

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Methods Mentioned

BETA
SMA

Software Mentioned

SPM
OptiMRI

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