Jan 1, 1977

Enhancement by a serum factor of immunoglobulin-mediated histamine release from human leukocytes

International Archives of Allergy and Applied Immunology
B A Petersson, G Stålenheim

Abstract

When serum was fractionated on Sephadex G-200, the material eluted in the second and thir major peaks had a very pronounced capacity to enhance IgE- as well as IgG-mediated histamine release from the leukocytes of both normal and allergic donors. Unseparated serum on the other hand had a low capacity to stimulate anti-IgE-induced histamine release. Besides resulting in a higher histamine release, pretreatment with serum fractions also increased the rate of histamine release. Further purification revealed that the stimulating activity of the material in the second peak was mediated by a trypsin-sensitive component, probably active in low concentration.

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Mentioned in this Paper

Anti-Immunoglobulin E antibody
Sephadex G 200
Immunoglobulin Activity
Immune Sera
White Blood Cell Count Procedure
Insulin Resistance
Immunoglobulins
Trypsin
Leukocytes
Immunoglobulin E

About this Paper

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