Enhancement by fluphenazine of dimethylbenz[a]-anthracene-induced mammary tumorigenesis in rats

Cancer Letters
M Shoyab

Abstract

Mammary tumor formation in female Sprague-Dawley rats was studied as a 2-stage protocol of initiation with 7,12 dimethylbenz[a]anthracene (DMBA) followed by repeated treatment with fluphenazine decanoate. No mammary tumors were found in the untreated control group or in the fluphenazine-treated groups. The repeated fluphenazine treatment was found to increase the number of mammary tumors in rats who had previously received DMBA and also to shorten the tumor latency period. The significance of these findings is discussed.

References

Aug 1, 1977·Computers and Biomedical Research, an International Journal·D G ThomasJ J Gart
Jan 1, 1969·Progress in Experimental Tumor Research·B L Van Duuren
Jan 1, 1974·CRC Critical Reviews in Toxicology·R K Boutwell
Jan 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P E Driedger, P M Blumberg

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Citations

Oct 5, 2011·Mutation Research·Giovanni BrambillaAntonietta Martelli
May 5, 2009·Toxicology·Giovanni BrambillaAntonietta Martelli
Oct 11, 2008·Mutation Research·Giovanni Brambilla, Antonietta Martelli
Jan 1, 1985·Teratogenesis, Carcinogenesis, and Mutagenesis·C M JoneC C Chang

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