PMID: 9162523Apr 1, 1996Paper

Enhancement in vivo of the antiinflammatory and antitumor activities of type I interferon by association with the synthetic immunomodulator murabutide

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
G M BahrL Chedid

Abstract

The therapeutic efficacy of type I interferon (IFN) has been reported to vary considerably in different indications. The use of the cytokine as adjuvant therapy has been suggested to enhance its efficacy and reduce the toxicity frequently associated with long-term and high-dose administration. In this study, we have assessed the activity of type I IFN in the protection against and treatment of acute hepatitis induced in mice by the administration of concanavalin-A (ConA). At the same time, we have evaluated the efficacy of the synthetic immunomodulator murabutide when administered alone or in combination with type I IFN to protect against ConA hepatitis and in the treatment of tumors in MethA sarcoma-bearing mice. Our results demonstrate a prophylactic effect as well therapeutic effects of type I IFN and of murabutide in the inflammation-mediated model of liver damage. The use of combination therapy presented enhanced efficacy in inhibiting the ConA-induced elevation of plasma transaminases. Both compounds were found to suppress IFN-gamma mRNA accumulation in the livers of ConA treated mice. This activity is discussed with respect to the mechanism of action of the two immunomodulators. In addition, the combination of murabutide...Continue Reading

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Citations

Sep 29, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E C DarcissacG M Bahr
Dec 6, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Eiji KajiwaraNaoki Yamashita
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie ChaputLaurence Zitvogel

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