PMID: 9096091Apr 1, 1997

Enhancement of [123I]beta-CIT binding in the striatum with clomipramine: is there a serotonin-dopamine interaction?

European Journal of Nuclear Medicine
M FujitaT Nishimura


Many reports support the concept of serotonergic-dopaminergic interaction in the brain. However, at present, there are few methods to study this relationship in vivo. The purpose of this study was to investigate the effect of serotonin (5-HT) uptake inhibitor, clomipramine, on a dopamine (DA) transporter ligand, [123I]beta-CIT (RTI-55), in rat brain. Dose-dependent changes in [123I]beta-CIT specific binding induced by clomipramine were studied in the striatum (rich in DA transporter) and the hypothalamus (rich in 5-HT transporter). The changes in the time-activity curves of [123I]beta-CIT specific binding after clomipramine injection were also examined in these two regions. Using the cerebellum as the reference region, k3 and k4 values with and without clomipramine administration were estimated by a two-compartment kinetic analysis. Clomipramine inhibited [123I]beta-CIT specific binding in the hypothalamus, but enhanced its specific binding in the striatum in a dose-dependent manner. Kinetic analysis showed that k3 in the striatum was increased by 55%. In conclusion, enhancement of [123I]beta-CIT binding in the striatum after clomipramine administration indicated the possibility of 5-HT-DA interaction.


Oct 31, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Jan Booij, Paul Kemp
Jun 26, 1999·Nuclear Medicine and Biology·S R ChoiH F Kung
Mar 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Werner ZitterlKenneth Thau


Sep 15, 1978·European Journal of Pharmacology·J Davies, P Tongroach
Feb 1, 1992·Neuropharmacology·O InoueT Suzuki
Jul 1, 1992·Journal of Pharmacological and Toxicological Methods·H T ChenD Goldman
Jan 1, 1990·Life Sciences·T SuharaK Kobayasi
Nov 1, 1990·British Journal of Clinical Pharmacology·S H SindrupH Beck-Nielsen
Jun 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J J FrostH N Wagner
Apr 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D F WongH N Wagner
Jan 1, 1973·Progress in Neurobiology·J M Sneddon
Mar 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M J BessonJ Glowinski
Apr 1, 1995·European Journal of Nuclear Medicine·J T KuikkaP Hakola
Dec 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·D K Arya
Nov 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M LaruelleR B Innis
Jul 15, 1994·European Journal of Pharmacology·S KitayamaG R Uhl
Jan 1, 1993·Journal of Neural Transmission. General Section·T BrückeI Podreka
May 1, 1993·Pharmacopsychiatry·C J McDougleL H Price
Feb 1, 1993·Trends in Pharmacological Sciences·B Giros, M G Caron
Apr 1, 1996·European Journal of Nuclear Medicine·M FujitaT Nishimura

Related Concepts

Tomography, Emission-Computed, Single-Photon
Clomipramine Maleate (1: 1)
Serotonin Measurement
Organum Vasculosum Laminae Terminalis
Lentiform Nucleus Structure

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.