Enhancement of 1,25-dihydroxyvitamin D3-mediated antitumor activity with dexamethasone

Journal of the National Cancer Institute
W D YuCandace S Johnson

Abstract

The active metabolite of vitamin D, i.e., 1,25-dihydroxycholecalciferol (1,25-D3), inhibits the growth of murine SCCVII/SF squamous cell carcinoma cells, both in vitro and in vivo. However, in vivo use of 1,25-D3 is hampered as a result of hypercalcemia (i.e., elevated levels of calcium in the blood). Glucocorticoids, such as dexamethasone, affect calcium absorption and modulate vitamin D receptor binding and have been used to treat hypercalcemia. In this study, we examined the effect of dexamethasone on tumor growth inhibition by 1,25-D3. The effects of 1,25-D3 and dexamethasone, alone and in combination, on the growth of SCCVII/SF cells in in vitro culture or in vivo in female C3H/HeJ mice were determined by clonogenic tumor cell assay and/or by actual changes in tumor volume. Vitamin D receptor-ligand-binding activities in whole-cell extracts from cells (in culture), tumors, and normal tissues were assayed by single-point saturation analysis and equilibrium binding. Treatment of cultured SCCVII/SF cells with 500 nM dexamethasone for 24 hours before addition of 1,25-D3 reduced their survival. The growth of SCCVII/SF tumors was inhibited in mice treated simultaneously with dexamethasone and 1,25-D3 (as compared with no treatme...Continue Reading

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Aug 25, 2017·Donald Trump, MD, Donald Trump, MD

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May 27, 2005·Cancer Chemotherapy and Pharmacology·Josephia R MuindiDonald L Trump
Oct 27, 2006·Cancer Chemotherapy and Pharmacology·Tomasz M BeerDonald L Trump
Feb 5, 2008·Cancer Chemotherapy and Pharmacology·Kenneth M RassnickDonald L Trump
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