Abstract
Subcutaneous injection of 1 mg/kg 5-hydroxytryptamine (5-HT) reduced the intake of a 10% sucrose solution in rats. A single injection of the monoamine oxidase inhibitor (MAOI) clorgyline enhanced the anorectic effect of 5-HT. Such an effect persists 2, 24, 48, 72 and 96 h after injection. The clorgyline treatment almost completely inhibited type A MAO activity in the liver at 2 h post-injection. By 120 h, the time at which potentiation of 5-HT induced anorexia disappeared, MAO-A activity had returned to 80% of control values. These results demonstrate that the clorgyline effect is long-lasting and irreversible. Brofaromine (5 mg/kg) and cimoxatone (20 mg/kg) also enhanced the anorectic effect of 5-HT injected 2 h later. The potentiating effects of brofaromine and cimoxatone were not observed when 5-HT was administered 24 h later. These results indicate that brofaromine and cimoxatone are short-acting, reversible inhibitors of MAO-A activity in vivo. Moclobemide (30 mg/kg) failed to enhance the anorectic action of 5-HT injected 2 and 24 h later. The potentiation of 5-HT induced anorexia may be a useful behavioural test for investigating the degree of reversibility, and time course of action of MAOIs.
References
Jan 1, 1988·Pharmacology, Biochemistry, and Behavior·F IselP Mandel
Jan 1, 1986·Psychopharmacology·A M Montgomery, M J Burton
Jan 1, 1988·Journal of Neural Transmission·S TurkishA J Greenshaw
May 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·P C Waldmeier
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·G PlanzD Palm
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Mar 1, 1983·The Journal of Pharmacy and Pharmacology·P DostertC Guffroy
Nov 1, 1984·The Journal of Pharmacy and Pharmacology·P DostertT Boucher
Oct 14, 1983·European Journal of Pharmacology·P C WaldmeierE Paul
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·P J Fletcher, M J Burton
Oct 14, 1983·European Journal of Pharmacology·P C WaldmeierK F Tipton
Mar 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·R OrtmannA Delini-Stula
Jun 16, 1982·European Journal of Pharmacology·N RowlandD Kocan
Apr 1, 1981·Journal of Neurochemistry·J P Kan, M Strolin Benedetti
Aug 1, 1981·Pharmacology, Biochemistry, and Behavior·J D Pollock, N Rowland
Citations
Jul 1, 1996·Physiology & Behavior·M A PrendergastS Balogh
Jan 5, 2013·Journal of Neurochemistry·Zhiyuan MaRui Tao
Mar 1, 1990·British Journal of Pharmacology·P J Fletcher, M Davies
Oct 26, 2005·Journal of Interpersonal Violence·Felicity W K HarperIleana Arias