Enhancement of adherence and growth of Chlamydia trachomatis by estrogen treatment of HeLa cells.

Infection and Immunity
S K Bose, P C Goswami

Abstract

Treatment of HeLa 229 cultures with 17-beta-estradiol or with diethylstilbestrol, a synthetic estrogen analog, prior to infection with Chlamydia trachomatis UW31 (serovar K) or LGV440 (serovar L1) led to a 50 to 60% enhancement of chlamydial inclusion formation. After infection, the presence of estrogen was required for the enhancement. The optimal concentration of estrogen required was 10(-10) M. At least 18 h of preinfection treatment plus 12 h of postinfection treatment was necessary. The adherence of purified radioactive elementary bodies of C. trachomatis to estrogen-treated HeLa cells was stimulated in an estrogen dose- and exposure-dependent manner. The requirements for both pre- and postinfection exposure to the hormone suggest that alterations in the cell membrane as well as in the metabolic capacity of the host cells is required for intracellular chlamydial development. Cycloheximide did not prevent estrogen enhancement of chlamydial adherence or subsequent intracellular development of inclusions.

References

Apr 1, 1978·The Journal of Infectious Diseases·J D OrielP Reeve
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Citations

Jun 10, 2005·Oral Microbiology and Immunology·M YokoyamaD Grenier
Mar 14, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tanvi AgrawalAruna Mittal
Jan 1, 2020·Current Clinical Microbiology Reports·Amy Berry, Jennifer V Hall
Jun 20, 1998·Sexually Transmitted Infections·C Sonnex
Mar 20, 2013·BioMed Research International·Elizabeth García-GómezIgnacio Camacho-Arroyo
Feb 1, 1993·Genitourinary Medicine·L Weström, P Wölner-Hanssen
Jan 13, 2018·Frontiers in Cellular and Infection Microbiology·Jennifer KintnerJennifer V Hall
Jun 22, 2018·Biology of Sex Differences·Edgar Ricardo Vázquez-MartínezBertha González-Pedrajo

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