Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons

Biomaterials
Giuseppe LamannaAlberto Bianco

Abstract

We have developed a straightforward method to prepare 1(st) and 2(nd) generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, in vitro. These results provide insights into the effect of HYDRAmer multivalency on biological interactions for therapeutic applications.

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Citations

Dec 21, 2013·Journal of the American Chemical Society·Maxime GrillaudAlberto Bianco
Feb 11, 2014·Journal of the American Chemical Society·Wei WuXiqun Jiang
Dec 15, 2012·Chemistry : a European Journal·Giuseppe LamannaAlberto Bianco
Aug 21, 2013·Journal of Tissue Engineering and Regenerative Medicine·Liliana R PiresAna Paula Pêgo
Oct 27, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·C S Chidan KumarHoong-Kun Fun
Jun 4, 2014·Biomaterials·Giuseppe LamannaAlberto Bianco
Dec 3, 2014·Journal of Peptide Science : an Official Publication of the European Peptide Society·Maxime Grillaud, Alberto Bianco
Aug 18, 2016·Molecular Pharmaceutics·Ana Judith Perisé-BarriosM Ángeles Muñoz-Fernández
Jul 14, 2018·Acta Crystallographica. Section E, Crystallographic Communications·Huey Chong KwongMd Azharul Arafath
Jun 6, 2015·Bioconjugate Chemistry·Julie RussierAlberto Bianco

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