Enhancement of anticancer potential of polyphenols by covalent modifications

Biochemical Pharmacology
Urszula LewandowskaSylwia Gorlach

Abstract

As evidenced by a growing number of respective clinical trials, a promising and increasingly valued approach to cancer prevention is chemoprevention which is based on using synthetic, semisynthetic, or natural compounds with the aim of preventing, delaying, arresting, or reversing carcinogenesis. Research carried out in the last two decades indicates that natural polyphenols isolated from plants (as well as their derivatives and synthetic analogs) exhibit pleiotropic actions toward cancer cells and therefore they could be used in both cancer prevention and therapy. This review discusses selected covalent modifications of polyphenols as a means for increasing their anticancer potential in relation to the parent compounds. The modifications include hydroxylation, methylation, acylation, and galloylation, among others. They were demonstrated to enhance cytotoxic, pro-oxidant, antiproliferative, proapoptotic, proautophagic, and antimigratory activities of phenolics toward various cancer cell lines in vitro. Importantly, some derivatives proved to suppress tumor growth and metastasis in animal models more strongly than the parent compounds. Some of the above-mentioned covalent modifications were also shown to increase absorption and...Continue Reading

References

Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jul 1, 1997·Cellular and Molecular Life Sciences : CMLS·D Salvemini
Feb 19, 1998·FEBS Letters·M FontecaveO Guittet
Apr 1, 1997·Nitric Oxide : Biology and Chemistry·K D KrönckeV Kolb-Bachofen
Mar 31, 2000·Molecular Medicine Today·L J McCawley, L M Matrisian
Aug 10, 2000·The Journal of Biological Chemistry·S L Oei, M Ziegler
Sep 7, 2000·Leukemia & Lymphoma·M B Møller
Mar 20, 2002·Nature Reviews. Cancer·R A Gupta, R N Dubois
Jun 4, 2002·Nature Reviews. Molecular Cell Biology·James C Wang
Dec 13, 2003·Cancer Letters·Krzysztof PolkowskiGrzegorz Grynkiewicz
May 12, 2004·Current Medicinal Chemistry·Giovambattista PaniTommaso Galeotti
May 15, 2004·Cell Death and Differentiation·A S AlvaE H Baehrecke
Jun 19, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P NoordhuisG J Peters
May 10, 2005·The International Journal of Biochemistry & Cell Biology·Manlio TolomeoDaniele Simoni
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·S-Y Sun
Mar 2, 2006·Current Oncology Reports·Toni K ChoueiriTarek M Mekhail
Jul 27, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Xia Wen, Thomas Walle
Sep 26, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Joshua D LambertChung S Yang
Feb 24, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Constantin TamvakopoulosPanayotis Pantazis
Jul 13, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Nga Ta, Thomas Walle
Nov 3, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ian T Johnson, Nigel J Belshaw
Mar 8, 2008·Journal of Medicinal Chemistry·Luís Sánchez-del-CampoJosé Neptuno Rodríguez-López
Apr 29, 2008·The Journal of Nutritional Biochemistry·Lucas Actis-GorettaCarl L Keen
Jul 29, 2009·Natural Product Reports·Alan CrozierMichael N Clifford
Jul 30, 2009·Cancer Prevention Research·Hong CaiAndreas J Gescher
Sep 22, 2009·Cancer Causes & Control : CCC·Akane UiIchiro Tsuji
Dec 4, 2009·The Journal of Investigative Dermatology·Verena PaulitschkeRainer Kunstfeld
Mar 9, 2010·Chemico-biological Interactions·Kanwal AhmedTakashi Kondo
Mar 10, 2010·Biochemistry. Biokhimii︠a︡·A V SorokinL P Ovchinnikov
Apr 14, 2010·International Journal of Molecular Sciences·Heidi Halbwirth
Jun 24, 2010·The Proceedings of the Nutrition Society·Mauro SerafiniAnna Raguzzini
Mar 5, 2011·Biological & Pharmaceutical Bulletin·Suratsawadee PiyaviriyakulNaoto Oku
Mar 18, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Michael G KellyThomas J Rutherford

❮ Previous
Next ❯

Citations

Apr 10, 2016·Planta·Adhityo WicaksonoJaime A Teixeira da Silva
Jan 12, 2017·Food & Function·J Abraham Domínguez-AvilaGustavo A González-Aguilar
Mar 3, 2018·International Journal of Molecular Sciences·Monika Gorzynik-DebickaMagdalena Gorska-Ponikowska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved