Enhancement of antigen driven lymphocyte proliferation secondary to GP41-induced B7 expression on adherent monocytes

Cellular Immunology
M A Kolber, M O Saenz

Abstract

HIV-1 viral proteins are known to have immune regulatory effects. The interplay between these molecules and the host immune cells is complex. In this study the immune regulatory effects of gp41 on lymphocyte proliferation were evaluated as a function of the state of the monocyte. It is shown that monocyte adherence to tissue culture plates prevents suppression of lymphocyte proliferation to recall antigen in the presence of gp41. In addition, gp41 can enhance proliferation to low concentrations of Casta antigen when PBL are permitted time to adhere. It is shown that these effects are in part mediated through enhanced expression of the costimulatory molecules B7 and CD40. Cyclosporin A was not able to fully abrogate gp41-enhanced proliferation, indicating participation of a calcium-independent pathway. In addition, concentrations of anti-IL2 receptor antibody sufficient to inhibit maximal proliferation to antigen did not fully inhibit PBL proliferation to antigen that is augmented with gp41. Taken together these results suggest that modification of the monocyte state of activation or differentiation could mediate a response to gp41 that is immune enhancing.

References

Dec 1, 1977·The Journal of Experimental Medicine·W D JohnsonZ A Cohn
Jan 1, 1992·Clinical and Experimental Immunology·S J BellR Penny
Feb 1, 1988·The Journal of Experimental Medicine·S B Clarkson, P A Ory
Sep 1, 1988·Immunology Letters·G J CiancioloR Snyderman
Jan 1, 1993·Annual Review of Immunology·P S Linsley, J A Ledbetter
Mar 7, 2000·Clinical and Diagnostic Laboratory Immunology·G M Graziani-Bowering, L G Filion
Aug 31, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Y LeJ Ming Wang

❮ Previous
Next ❯

Citations

Jul 30, 2003·Journal of Leukocyte Biology·Nitza LahatHaim Bitterman
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Audrey L KinterAnthony S Fauci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.