Enhancement of antitumor vaccine in ablated hepatocellular carcinoma by high-intensity focused ultrasound.

World Journal of Gastroenterology : WJG
Ying ZhangFeng Wu

Abstract

To investigate whether tumor debris created by high-intensity focused ultrasound (HIFU) could trigger antitumor immunity in a mouse hepatocellular carcinoma model. Twenty C57BL/6J mice bearing H22 hepatocellular carcinoma were used to generate antitumor vaccines. Ten mice underwent HIFU ablation, and the remaining 10 mice received a sham-HIFU procedure with no ultrasound irradiation. Sixty normal mice were randomly divided into HIFU vaccine, tumor vaccine and control groups. These mice were immunized with HIFU-generated vaccine, tumor-generated vaccine, and saline, respectively. In addition, 20 mice bearing H22 tumors were successfully treated with HIFU ablation. The protective immunity of the vaccinated mice was investigated before and after a subsequent H22 tumor challenge. Using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, the cytotoxicity of splenic lymphocytes co-cultured with H22 cells was determined in vitro before the tumor challenge, and tumor volume and survival were measured in vivo after the challenge in each group. The mechanism was also explored by loading the vaccines with bone marrow-derived dendritic cells (DCs). Compared to the control, HIFU therapy, tumor-generated and HIFU-generate...Continue Reading

References

Mar 15, 1993·Journal of Immunological Methods·R F HussainR T Oliver
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Sep 7, 2002·Fertility and Sterility·Nathaniel M FriedStephen B Solomon
Aug 21, 2003·Lancet·A Graham Pockley
Jun 3, 2004·Cancer Research·Martijn H M G M den BrokGosse J Adema
Nov 20, 2004·Ultrasound in Medicine & Biology·Feng WuCheng-Bing Jin
Mar 19, 2005·Nature Reviews. Cancer·James E Kennedy
Aug 2, 2005·Biochemical and Biophysical Research Communications·Zhenlin HuPei Zhong
Feb 14, 2006·Nature Clinical Practice. Urology·Christian ChaussyAlbert Gelet
May 18, 2006·Minimally Invasive Therapy & Allied Technologies : MITAT : Official Journal of the Society for Minimally Invasive Therapy·Feng Wu
Aug 26, 2006·Progress in Biophysics and Molecular Biology·Gail ter Haar
Apr 20, 2007·Journal of Surgical Oncology·Feng WuJiang-Zhong Zou
Jul 13, 2007·Journal of Translational Medicine·Zhenlin HuPei Zhong
Nov 6, 2007·Annals of the New York Academy of Sciences·Michael Sherman, Gabriele Multhoff
Jun 20, 2008·Physics in Medicine and Biology·D E KruseK W Ferrara
Sep 19, 2008·Immunity·Cornelis J M Melief

❮ Previous
Next ❯

Citations

Apr 1, 2014·Advanced Drug Delivery Reviews·Johan Unga, Mitsuru Hashida
Aug 10, 2013·The Journal of the Acoustical Society of America·Feng Wu
Dec 29, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Li-Feng RanFeng Wu
Jan 26, 2016·Journal of Therapeutic Ultrasound·Or Cohen-InbarJason P Sheehan
Jan 24, 2012·Journal of Vascular and Interventional Radiology : JVIR·Bertrand Janne d'OthéeStephen T Kee
Mar 8, 2011·Surgical Oncology Clinics of North America·John F Ward
Oct 2, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Christopher BastianpillaiManit Arya
Jan 14, 2012·Clinical & Developmental Immunology·Sebastian P HaenCécile Gouttefangeas
Sep 3, 2016·Cancer Immunology, Immunotherapy : CII·Renske J E van den BijgaartGosse J Adema
Oct 27, 2016·Ultrasound in Medicine & Biology·Roberta CirincioneFrancesco Paolo Cammarata
Nov 13, 2019·Nature Reviews. Clinical Oncology·Martin J ConnorHashim U Ahmed
Dec 5, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mohit Pratap SinghAshish Ranjan
Jan 10, 2018·Asia-Pacific Journal of Clinical Oncology·Wuwei YangGuangxian Liu
Oct 21, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jordan B JoinerPaul A Dayton
Jan 16, 2021·The Urologic Clinics of North America·Sujit S NairAshutosh K Tewari
Jun 3, 2021·Cancers·Ather AdnanRahul A Sheth
Jul 27, 2021·Frontiers in Oncology·Karl-Göran Tranberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.