PMID: 9525667Apr 3, 1998Paper

Enhancement of aquareovirus infectivity by treatment with proteases: mechanism of action

Journal of Virology
T H McPhillipsS K Samal

Abstract

The effects of protease digestion on the polypeptide composition and on the infectivity of striped bass virus, an aquareovirus, were examined. Both trypsin and chymotrypsin enhanced the infectivity of the virus. Enhancement of infectivity was correlated with the digestion of the outer capsid protein, VP7. These studies support the assertion that VP7 is the outermost capsid protein and suggest that VP4 and VP5 are exposed on the outer surface of infectious particles. The possible role of VP7 in the variation in virulence observed among aquareovirus isolates is discussed.

References

Sep 1, 1981·Journal of Virology·S M ClarkR S Spendlove
Jan 1, 1981·Journal of Virology·R T EspejoC Arias
Sep 1, 1981·Journal of Virology·M K EstesB B Mason

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Citations

Jan 6, 2006·Rapid Communications in Mass Spectrometry : RCM·Ita HadzisejdićKevin M Coombs
Jun 23, 2000·Journal of Virology·E L NasonB V Venkataram Prasad
Sep 12, 2001·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·S Essbauer, W Ahne
Mar 6, 2018·The Journal of Eukaryotic Microbiology·Marcel D O Pinheiro, Niels C Bols

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