Abstract
It is well established that viral infections may precipitate or worsen attacks of bronchial asthma. Furthermore, in symptomatic atopic subjects, the local accumulation of basophils and the production of a basophil chemotactic factor have been reported. We have investigated the effect of cell-free supernates from viral stimulated cultures of human mononuclear cells on the in vitro migration of human basophils. Our results show the presence of a factor in these culture supernates that enhances the migration of basophils toward two separate chemoattractants, a peptide from C5 and a lymphokine. The enhancing activity, while affecting basophil migration, did not change the response of monocytes. The enhancing activity resembled viral-induced interferon when (a) pH 2 stability, (b) heat resistance, (c) trypsin sensitivity, and (d) species-specificity were compared. Finally, the enhancing activity for basophil chemotaxis and the interferon titer were highly correlated in preparations with a 10(4)-fold difference in interferon specific activity. Our studies show that viral-induced interferon can augment the in vitro chemotactic response of basophils. Because mediators present in basophils may be involved in the pathogenesis of immediat...Continue Reading
References
Nov 1, 1975·Journal of Immunological Methods·E J Leonard
Apr 1, 1977·The Journal of Experimental Medicine·S IdaA L Notkins
Nov 7, 1977·Biochemical and Biophysical Research Communications·M F MeldolesiL D Kohn
Jul 1, 1978·The Journal of Pediatrics·C B HallJ M Geiman
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M G ToveyM Castagna
Jul 5, 1979·The New England Journal of Medicine·J J HooksA L Notkins
Jul 1, 1978·The Journal of Pediatrics·K McIntosh
Jun 1, 1976·Scandinavian Journal of Immunology·A Bøyum
Mar 1, 1975·Clinical Allergy·I KimuraS Sato
Aug 20, 1971·Science·H R BourneL M Lichtenstein
Jun 1, 1973·Clinical Allergy·I KimuraY Tanizaki
Oct 1, 1966·Clinical Pediatrics·G L Freeman
Apr 1, 1973·The Journal of Pediatrics·K McIntoshV A Fulginiti
Jan 21, 1974·JAMA : the Journal of the American Medical Association·T E MinorC E Reed
Nov 1, 1965·The Journal of Allergy·J J Ouellette, C E Reed
Apr 17, 1980·Nature·B R Bloom
Jan 24, 1980·Nature·J E Blalock, J D Stanton
Apr 1, 1980·The Journal of Allergy and Clinical Immunology·S R Hirsch, J H Kalbfleisch
Oct 1, 1962·American Journal of Diseases of Children·G L FREEMAN, R H TODD
Citations
Nov 1, 1992·Journal of Virological Methods·J M StarkM F Tosi
Oct 1, 1989·The Journal of Experimental Medicine·N Matsuura, B R Zetter
Feb 1, 1988·Plant Physiology·T C OsbornF A Bliss
Jun 1, 1992·Allergy·P ClementsenS Norn
May 1, 1991·The American Review of Respiratory Disease·R P SchleimerB S Bochner
Apr 1, 1991·American Journal of Respiratory Cell and Molecular Biology·W W BusseE C Dick
Apr 1, 1987·Immunological Investigations·M P LangfordJ A Grant
Nov 1, 1988·Immunological Investigations·G Marone
Jan 1, 1985·Chest·W W Busse
Apr 1, 1990·The Journal of Allergy and Clinical Immunology·W W Busse
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·B S BochnerR P Schleimer
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·L H ThomasJ A Warner
May 1, 1990·The Journal of Allergy and Clinical Immunology·J T LiG J Gleich
Jan 1, 1986·The British Journal of Dermatology·E B MitchellT A Platts-Mills
Nov 1, 1991·The Journal of Allergy and Clinical Immunology·J A GrantM A Lett-Brown
Aug 1, 1981·Clinical Immunology and Immunopathology·M A Lett-BrownJ A Grant
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W W Busse
Mar 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J Shute
Sep 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P G BardinP K Pattemore
Nov 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y TanimotoI Kimura
Jan 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W W Busse
Apr 26, 2003·Cytopathology : Official Journal of the British Society for Clinical Cytology·M CourtadeC Caratero
Jan 16, 2021·Cell·Fang WangBrian S Kim
Jun 11, 1992·Chest·W W BusseE C Dick