Enhancement of biological activities of nanostructured hydrophobic drug species

Nanoscale
Qiusen HanChen Wang

Abstract

We report a study of nanoribbons of quercetin, a phase I clinical trial anticancer drug, and their inhibitory effects on cancer cell proliferation. Novel quercetin nanoribbons have been prepared by atmospheric pressure physical vapor deposition (PVD). The nanostructures have been characterized by optical microscopy, scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy, etc. Significantly enhanced solubility in PBS solution and increased drug release rate have been observed for quercetin nanoribbons in comparison to those of quercetin powder. The observed increase of inhibitory effects of quercetin nanoribbons on 4T1 cancel cell growth is correlated with an improvement in their solubility and drug release behavior.

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Citations

Jan 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ju-Suk NamSang-Soo Lee
Jul 19, 2013·Expert Opinion on Drug Delivery·Shengpeng WangYitao Wang
Jan 11, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Amit K JainSanyog Jain
Jan 1, 2014·Nutrition and Cancer·Katrin Sak
Oct 28, 2017·Future Medicinal Chemistry·Domenico IacopettaMaria Stefania Sinicropi
Jan 2, 2019·Cancers·Mariam AbotalebDietrich Büsselberg
May 7, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Sergio MurgiaClaudia Caltagirone

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