PMID: 15348249Sep 7, 2004Paper

Enhancement of bone ingrowth in a titanium fiber mesh implant by rhBMP-2 and hyaluronic acid

Journal of Materials Science. Materials in Medicine
S ItohK Shinomiya

Abstract

The present study was designed to evaluate the efficacy of high molecular weight hyaluronic acid (HA) used as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) adsorbed to a titanium fiber mesh implant (TFMI) in vivo. The quantity of HA in the TFMI rapidly decreased during the initial 3-day period after implantation. BMP particles were trapped by the meshwork of HA as observed by scanning electron microscopy (SEM). TFMIs containing LF-6, HA, rhBMP-2, or HA combined with rhBMP-2 were implanted on the cranium of rats. Analysis of digitized SEM images of samples obtained six weeks post-implantation was performed to determine the area occupied by new bone. The area fraction of Ca relative to that of the pores of TFMI in the HA group was larger than that in the Ti group (p<0.05). The area fraction of Ca in both the BMP and HA+BMP groups was larger than that in both the Ti and HA groups (p<0.01), and that in the HA+BMP group was larger than that in the BMP group (p<0.05). It is suggested that HA is not only an effective carrier of BMP, but also it may have a positive effect on the generation of new bone in the TFMI.

Citations

Aug 13, 2020·Drug Delivery and Translational Research·Tori Czech, Moses O Oyewumi
Mar 1, 2006·Journal of Biomedical Materials Research. Part a·Yang-Jo SeolChong-Pyoung Chung
Sep 2, 2006·Journal of Periodontology·Barbara D BoyanZvi Schwartz
Apr 3, 2008·Journal of Tissue Engineering and Regenerative Medicine·P C BessaR L Reis
Mar 28, 2017·Pharmaceutical Research·Inas El BialyM Reza Nejadnik
Nov 11, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Marco MorraRoberto Giardino
Oct 12, 2013·Journal of Materials Science. Materials in Medicine·Matthias C SchulzVera Hintze
May 3, 2016·Orthodontics & Craniofacial Research·T B SadikogluN Ulas
May 10, 2007·Expert Review of Medical Devices·Marco Morra
Feb 24, 2011·Biotechnology Letters·Jin-Woo ParkChang-Hyeon An
Feb 14, 2019·International Journal of Molecular Sciences·Saturnino Marco LupiRuggero Rodriguez Y Baena
Jan 19, 2021·ACS Biomaterials Science & Engineering·Hee Yun JangJin Ho Lee
Aug 12, 2008·Archives of Oral Biology·Renato M MendesAnderson J Ferreira

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