PMID: 9541656Apr 29, 1998Paper

Enhancement of bone marrow radioprotection and reduction of WR-2721 toxicity by Ocimum sanctum

Mutation Research
A GanasoundariB S Rao

Abstract

The radioprotective effect of the leaf extract of Ocimum sanctum (OE) in combination with WR-2721 (WR) was investigated on mouse bone marrow. Adult Swiss mice were injected intraperitoneally (i.p.) with OE (10 mg/kg on 5 consecutive days), or 100-400 mg/kg WR (single dose) or combination of the two or double-distilled water (DDW) and whole-body exposed to 4.5 Gy gamma-irradiation (RT). Metaphase plates were prepared from femur bone marrow on days 1, 2, 7 and 14 post-treatment and chromosomal aberrations were scored. The maximum number of aberrant cells was observed at 24 h after irradiation in all the groups. However, pretreatment with OE or WR individually resulted in a significant decrease in aberrant cells as well as different types of aberrations. The combination of the two further enhanced this effect; resulting in a 2-fold increase in the protection factor (PF = 6.68) compared to 400 mg/kg WR alone. The percent aberrant cells decreased linear-quadratically with WR dose when given individually, while in the OE + WR pretreatment animals the values showed a linear dose response. Combination of OE with WR doses above 200 mg/kg completely eliminated rings, polyploidy and pulverization of chromosomes. Percent aberrant cells dec...Continue Reading

References

Jan 1, 1990·Pharmacology & Therapeutics·E A Bump, J M Brown
Jun 1, 1988·International Journal of Radiation Oncology, Biology, Physics·M M KligermanP Rubin
Jan 1, 1988·Pharmacology & Therapeutics·P Uma Devi, B Thomas
Sep 1, 1985·Acta Radiologica. Oncology·R Gupta, P Uma Devi
Jun 1, 1986·The British Journal of Radiology·R Gupta, P Uma Devi
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M L MeistrichL Milas
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G L Jensen, A Meister

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Citations

Mar 31, 2005·Phytotherapy Research : PTR·Rajesh AroraRakesh Kumar Sharma
Jul 27, 2001·Mutation Research·M SatyamitraV T Kagiya
May 25, 2013·Nutrition and Cancer·Manjeshwar Shrinath BaligaPrincy L Palatty
Dec 23, 2009·Cancer Biotherapy & Radiopharmaceuticals·Seyed Jalal Hosseinimehr
Mar 5, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Somashekar ShettyLaxminarayana Udupa
Oct 21, 2010·Molecular Cytogenetics·Joshua B StevensHenry H Heng
Jan 1, 2010·Pharmacognosy Reviews·Priyabrata PattanayakSangram K Panda
Mar 21, 2008·Mutagenesis·Sudheer K MantenaP Uma Devi
Sep 15, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y DuanY Qin
Oct 15, 2010·Journal of Cellular Physiology·You Sun AnJae Youn Yi
Dec 16, 2005·Redox Report : Communications in Free Radical Research·Mahesh SubramanianSubrata Chattopadhyay
Apr 14, 2016·Journal of Cancer Research and Therapeutics·Manjeshwar Shrinath BaligaPrema D'souza
Apr 22, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·V BenkovicN Kopjar
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javad Sharifi-RadMarcello Iriti
Oct 26, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tatiana IvanovaJie-Young Song
Jan 1, 2005·Environmental Toxicology and Pharmacology·Mukesh Kumar SharmaAshok Kumar
Mar 24, 2018·Scientific Reports·Marshleen YadavNaduparambil K Jacob
Oct 7, 2000·Radiation Research·P Uma DeviM K Unnikrishnan
May 26, 2021·The Science of the Total Environment·Mohammed Junaid Hussain DowlathD Duc Nguyen
Dec 25, 2007·Mutation Research·S K MantenaT Mukherjee

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