PMID: 11309799Apr 20, 2001Paper

Enhancement of bone regeneration using resorbable ceramics and a polymer-ceramic composite material

Journal of Biomedical Materials Research
H Schliephake, T Kage

Abstract

The aim of this experimental study was to evaluate the use of resorbable implants for the repair of nonloaded skeletal defects. Porous ceramic implants of alpha-TCP, of glass-ceramic, and of solid composite implants of glass-ceramic/polylactic acid 8 mm in diameter and 2 mm in thickness were fabricated and implanted pressfit into biparietal, full-thickness defects of the calvaria of 60 adult rats. Twenty rats received unfilled defects and served as controls. Fluorochrome labeling of bone formation was performed during the observation period. Five animals from each group were evaluated after 6, 13, 26, and 52 weeks. The control defects showed incomplete regeneration, with bone formation extending 1.66 mm, on average, into the defect after 52 weeks. In the group of alpha-TCP implants, histologic evaluation indicated that the bone formed during initial stages had undergone resorption later on, so that bone repair after 52 weeks was not significantly enhanced, with an average depth of 1.83 mm of bone ingrowth. The glass-ceramic implants exhibited extensive bone formation and nearly complete repair of the calvarial defect, with 3.90 mm of bone ingrowth into the implant pores. Degradation of the ceramic was nearly complete, with a fe...Continue Reading

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Citations

Jun 5, 2007·Journal of Materials Science. Materials in Medicine·M Wiedmann-Al-AhmadR Schmelzeisen
Jan 12, 2005·Clinical Oral Implants Research·Christine KnabeHala Zreiqat
Nov 16, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Masahiro YamadaShohei Kasugai
Jun 8, 2013·Clinical Oral Implants Research·André VajgelNikolaos Donos
Jun 5, 2013·Journal of Biomedical Materials Research. Part a·F G DraenertW E G Mueller
Apr 20, 2005·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Fabio Franceschini MitriBruno König Júnior
Dec 4, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Alok JainChristine Peter
Nov 10, 2009·Journal of Dental Research·Y SuzukiO Suzuki
May 6, 2004·Journal of Biomedical Materials Research. Part a·H SchliephakeS Scholz
Apr 15, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Angela Leão AndradeRosana Zacarias Domingues
May 9, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hidemichi KiharaShohei Kasugai
Nov 19, 2005·Expert Review of Medical Devices·Ahmed El-Ghannam
Nov 4, 2005·Plastic and Reconstructive Surgery·Harvey Chim, Jan-Thorsten Schantz

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