PMID: 9167844May 1, 1997Paper

Enhancement of brain p0(2) during cardiopulmonary bypass using a hyperosmolar oxygen carrying solution

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
T M RungeJ R Ybarra

Abstract

During the past decade a new syndrome has been recognized: cerebral hypoxia secondary to cardiopulmonary bypass, resulting in impairment of cognitive memory. The incidence of the syndrome appears to be no less that 30% in patients over 65 years of age undergoing cardiac surgery. There are several factors contributing to hypoxia produced by cardiopulmonary bypass. One of these factors is crystalloid pump prime and replacement solutions devoid of (1) oxygen carrying capacity and (2) devoid of protein and its colloid osmotic pressure. This shortcoming of cardiopulmonary crystalloid solutions is partially responsible for two of the three major pathologic effects of cardiopulmonary bypass: (1) hypoxia (2) interstitial fluid accumulation (anasarca, water-logging, edema). This report describes an oxygen carrying hyperosmolar solution which enhances brain p0(2) and diminishes interstitial fluid accumulation. This blood substitute consists of perfluorcarbons and saccharides, but could consist of a hemoglobin variant plus hyperosmolar ingredients other than saccharides. The advantage of a perfluorochemical is its ability to access small channels and to be centrifuged off the patient post-operatively with a cell saver. The advantage of sa...Continue Reading

References

Jan 11, 1991·The Annals of Thoracic Surgery·J A SwainR C Robbins
Apr 12, 1986·Lancet·P L SmithM J Harrison
Nov 16, 1985·British Medical Journal·P J ShawD A Shaw
Jan 1, 1981·Archives of Neurology·K A SotaniemiE T Hokkanen
May 1, 1995·The Annals of Thoracic Surgery·J M MurkinJ A Blumenthal
Oct 7, 1993·The New England Journal of Medicine·J A Swain
Jul 1, 1994·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J C Briceno, T M Runge

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.