Enhancement of cationic antimicrobial materials via cholesterol incorporation

Advanced Healthcare Materials
Daniel J CoadyJames L Hedrick

Abstract

Cationic antimicrobial materials are an attractive option for treating drug-resistant bacteria. Their membrane lytic mechanism can provide broad spectrum antimicrobial activity while largely negating natural resistance development. Selectivity is achieved using non-specific electrostatic interactions since microbial membranes display significantly more peripheral negative charge than due eukaryotic bilayers. Following membrane association, structural changes occur causing bilayer destabilization and cell lysis. Herein, antimicrobial effects of enhanced membrane assimilation are examined. Cholesterol, a functionalizable small molecule that assimilates abundantly within cell membranes, is chosen to increase membrane penetration ability to improve antimicrobial activity. Furthermore, cholesterol has an ability to template interesting nanostructures due to its propensity for rotative face-on-face stacking. The installation of cationic polycarbonates with systematically varied chain lengths from three separate cholesteryl initiators is accomplished using organocatalytic ring-opening polymerization. Introduction of cholesteryl oligomers into aqueous media creates "coin" shaped self-assemblies possessing high exterior cationic charge ...Continue Reading

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Citations

May 10, 2017·ACS Applied Materials & Interfaces·Fan HuangJianfeng Liu
Jun 11, 2019·Nanoscale·Yu-Fon ChenJeng-Shiung Jan
May 14, 2018·Polymer Chemistry·Shrinivas VenkataramanYi Yan Yang
May 16, 2017·Advanced Healthcare Materials·Jeremy P K TanJames L Hedrick
Sep 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ashlynn L Z LeeYi Yan Yang
Dec 15, 2015·Beilstein Journal of Organic Chemistry·Mohamed Ramadan El Sayed AlyShams Hashim Abdel-Hafez
Jun 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yongmao LiWenguang Liu
Aug 19, 2020·Inorganic Chemistry·Soumalya BhattacharyyaPartha Sarathi Mukherjee
Oct 7, 2021·Advanced Materials·Kenward JungCyrille Boyer

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