Enhancement of cerebral diseases: how much contrast agent is enough? Comparison of 0.1, 0.2, and 0.3 mmol/kg gadoteridol at 0.2 T with 0.1 mmol/kg gadoteridol at 1.5 T

Investigative Radiology
C BrekenfeldH B Gehl

Abstract

To determine the clinical dose of gadoteridol (ProHance, Bracco-Byk Gulden) to use for the assessment of blood-brain barrier breakdown on low-field magnetic resonance (MR) scanners that corresponds to a standard dose of gadoteridol on high-field MR scanners. This prospective study was carried out at four centers. A total of 138 patients with suspected or known brain diseases underwent a routine head scan comprising precontrast T2-weighted turbo spin-echo and T1-weighted spin-echo sequences on a 1.5-T MR scanner. After administration of a standard dose of 0.1 mmol/kg gadoteridol, the T1-weighted scan was repeated after a delay of 15 to 20 minutes. For continuing the examination on a 0.2-T MR scanner (Magnetom OPEN, Siemens), a standard-dose T1 spin-echo sequence was started within 30 to 50 minutes of the first injection. Then two additional T1-weighted low-field sequences were each started 5 minutes after two additional doses of 0.1 mmol/kg gadoteridol. Eighty patients with enhancing lesions underwent an intraindividual comparison. Evaluation of the overall numbers of lesions detected and of lesion size and character was performed on-site as well as off-site by two independent readers. The single-dose, low-field sequence detecte...Continue Reading

References

Jul 1, 1990·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·P SchubeusR Felix
Nov 1, 1990·Radiology·V M RungeG Heard
Sep 1, 1988·Radiology·P A RinckR N Muller
Sep 1, 1985·Radiology·R FelixU Speck
Apr 1, 1984·Radiology·L E CrooksL Kaufman
Feb 18, 1998·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·A J LemkeR Felix

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Citations

Mar 8, 2002·Investigative Radiology·Iris-Melanie Nöbauer-HuhmannSiegfried Trattnig
Jun 25, 2003·Investigative Radiology·Ahmed Ba-SsalamahSiegfried Trattnig
Nov 20, 2003·Topics in Magnetic Resonance Imaging : TMRI·Nilesh K Desai, Val M Runge
Jan 2, 2007·Topics in Magnetic Resonance Imaging : TMRI·Marco EssigFrederik L Giesel
Nov 1, 2001·Topics in Magnetic Resonance Imaging : TMRI·V M Runge
May 15, 2013·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Kazuhiro TsuchiyaAkira Kunimatsu
Aug 11, 2006·The New England Journal of Medicine·Raphaela Goldbach-ManskyDaniel L Kastner
Aug 13, 2009·European Radiology·Marco EssigMatthias Voth
Nov 1, 2001·Topics in Magnetic Resonance Imaging : TMRI·V M RungeJ R Jinkins
Jul 23, 2021·Investigative Radiology·Masaaki HoriShigeki Aoki

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