Enhancement of class II-restricted T cell responses by costimulatory NK receptors for class I MHC proteins

Science
O MandelboimJ L Strominger

Abstract

An important feature of the human immune system is the ability of T cells to respond to small quantities of antigen. Class II major histocompatibility complex (MHC)-restricted T cells that expressed a costimulatory natural killer (NK) cell receptor for class I MHC proteins were cloned. In the presence of low doses of superantigen, the proliferative response of these T cell clones was three- to ninefold greater when the T cells were costimulated by way of the NK receptor. Thus, the action of costimulatory NK receptors on T cells may play a significant role in initiating and sustaining immune responses.

References

Jan 1, 1992·Annual Review of Immunology·J F Miller, G Morahan
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E CicconeA Moretta
Nov 16, 1995·Nature·J E Gumperz, P Parham
Oct 1, 1994·Current Opinion in Immunology·V A BoussiotisL M Nadler
Jun 1, 1995·Blood Reviews·S M Richards
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M ColonnaJ L Strominger
Jan 1, 1995·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·M A Charleston
Jan 1, 1996·Annual Review of Immunology·A MorettaL Moretta

❮ Previous
Next ❯

Citations

Jul 11, 2006·Immunogenetics·Des C JonesNeil T Young
Dec 31, 2003·Trends in Immunology·Melissa R SnyderJörg J Goronzy
Sep 9, 1999·Journal of Reproductive Immunology·C MünzH G Rammensee
Feb 5, 2000·Human Immunology·M Valés-GómezJ Strominger
Aug 11, 2001·Current Opinion in Immunology·C W McMahon, D H Raulet
Nov 22, 1997·Current Opinion in Immunology·A Moretta, L Moretta
Jun 1, 1997·Current Opinion in Immunology·E O Long, N Wagtmann
Jun 1, 1997·Current Opinion in Immunology·C A Chambers, J P Allison
Dec 16, 1998·Ryōikibetsu shōkōgun shirīzu·K Kawa
Apr 4, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tian-Yu YangYong Zhao
Apr 27, 2002·Scandinavian Journal of Immunology·M FlodströmH-G Ljunggren
Apr 19, 2000·The Journal of Experimental Medicine·H R SmithW M Yokoyama
Mar 3, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Craig S ClementsJamie Rossjohn
May 23, 1998·Annual Review of Immunology·L L Lanier
Jun 8, 1999·Annual Review of Immunology·E O Long
Mar 13, 2001·Annual Review of Immunology·D H RauletC W McMahon
Feb 28, 2002·Annual Review of Immunology·Carlos Vilches, Peter Parham
Mar 18, 2005·Annual Review of Immunology·Lewis L Lanier
Oct 9, 2002·The Journal of Clinical Investigation·Gal MarkelOfer Mandelboim
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·M Valés-GómezJ Strominger
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·O MandelboimJ L Strominger
Feb 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Craig S ClementsJames McCluskey
Dec 10, 1999·Tropical Medicine & International Health : TM & IH·E MavoungouJ Lansoud-Soukate
Nov 22, 1997·European Journal of Immunology·D M DavisJ L Strominger
Sep 28, 1999·Current Opinion in Neurology·G Martino, H P Hartung
Mar 7, 2002·International Reviews of Immunology·K S Campbell, M Colonna
May 19, 1997·The Journal of Experimental Medicine·B DasA J Norin
Jan 7, 1998·The Journal of Experimental Medicine·W M Yokoyama
Feb 12, 1998·The Journal of Experimental Medicine·K M BrumbaughP J Leibson
Nov 19, 2004·European Journal of Immunology·Lionel ArlettazBertrand Huard
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Medhat AskarNizar N Zein
Mar 1, 1997·Immunity·O MandelboimJ L Strominger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.