Enhancement of cytomegalovirus infection and acute rejection after allogeneic lung transplantation in the rat

Transplantation
G SteinhoffA Haverich

Abstract

A possible mechanism of the induction of lung transplant rejection by cytomegalovirus (CMV) infection is the inflammatory upregulation of adhesion ligand molecules on transplant endothelia by the viral infection leading to leukocyte activation. To study this question a rat model of rat cytomegalovirus (RCMV) infection and acute lung transplant rejection was established to study: (1) the influence of RCMV infection on the course of rejection, (2) the influence of rejection on the course of RCMV infection, and (3) the influence of RCMV on adhesion molecule expression and leukocyte infiltration. For this Lew (RT1l) rats received either syngenic (n=25) or allogeneic (BN, RT1n; n=38) left lateral lung transplants. Postoperatively, CsA 25mg/kg was given on days 1-3 and triple drug (CsA, Aza, Pred) immunosuppression was given from days 4-10 to induce systemic RCMV infection and acute rejection developed from postoperative day (POD) 15-25 in allogeneic transplants. In RCMV-positive animals the rejection grade was gradually increased at POD 15 and 18. Furthermore, after allogeneic transplantation an enhanced viral infection of the lung transplant as early as POD 11 was found and increased salivary gland PFU titers on days 20 and 25. In ...Continue Reading

References

Jun 23, 1989·JAMA : the Journal of the American Medical Association·M T GrattanN E Shumway
Jun 23, 1989·JAMA : the Journal of the American Medical Association·R H Rubin
Jan 1, 1985·Intervirology·C A BruggemanC P van Boven
Jan 1, 1986·Archives of Virology·C A BruggemanC P van Boven
Jun 1, 1986·Transplantation·J H BruningP J van Breda Vriesman
Jan 1, 1983·Archives of Virology·C A BruggemanC P van Boven
Aug 1, 1993·The Journal of Experimental Medicine·M S MulliganP A Ward
Sep 1, 1993·The American Review of Respiratory Disease·T UyamaJ Prop
Jul 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·J UstinovI Lautenschlager
Jan 1, 1993·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T WahlersH G Borst
Sep 1, 1993·Journal of Virology·M BalthesenM J Reddehase

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Citations

Mar 20, 1999·Transplantation Proceedings·A E Frost
Nov 2, 1999·Transplant Immunology·A T BorchersM E Gershwin
Feb 11, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·M BrandtA Haverich
Mar 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heyman LuckrazJohn Wallwork
Sep 6, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heyman LuckrazStephen R Large
Apr 15, 1999·Clinical Transplantation·A H TirokeA Haverich
Sep 23, 2009·Pancreas·Maaike J SmeltPaul de Vos
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·C GerstenkornD Talbot
Sep 11, 2002·The Lancet Infectious Diseases·Francesca Cainelli, Sandro Vento
Oct 3, 2006·Current Opinion in Anaesthesiology·J BriegelM Haller
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MarteliusI Lautenschlager
Sep 16, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Karsten WiebeGustav Steinhoff
Jun 9, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·K LehleS W Hirt
May 7, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Antoine RouxVictor Appay
Dec 24, 2010·Cell Transplantation·M J SmeltP de Vos
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·R LaBicheT J DeGraba

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