PMID: 6169978Jan 1, 1981Paper

Enhancement of cytotoxicity of human peripheral blood lymphocytes by interferon

Microbiology and Immunology
T Kato, T Minagawa

Abstract

Human lung carcinoma cells persistently infected with mumps virus (Pc-10/MpV) were lysed with human peripheral blood mononuclear leukocytes (PBML) obtained from seropositive donors who had anti-mumps virus-neutralizing antibody in their sera. This cellular cytotoxicity was due not to the cytotoxic T lymphocytes but mainly to the non-T, non-B cells, possibly related to natural killer (NK) cells. Moreover, it was concerned not with antibody against mumps virus antigens but with alpha-interferon (IFN-alpha) produced in the mixture of human PBML and Pc-10/MpV cells, since this cellular cytotoxicity was suppressed by anti-human IFN-alpha rabbit serum. Exogeneous IFN-alpha augmented the cytotoxicity of non-T, non-B cells, not T cells, for the uninfected Pc-10 cells. IFN-gamma that had been induced by heat-killed Listeria monocytogenes in PBML had the same capacity to augment NK activity did IFN-alpha.

References

Apr 1, 1979·The Journal of Experimental Medicine·T J Braciale
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Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P LindahlI Gresser
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Apr 1, 1980·The Journal of Experimental Medicine·J Y DjeuR B Herberman
Jul 1, 1980·The Journal of Experimental Medicine·N MinatoB R Bloom
Jun 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M G MasucciW Berthold
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Jan 1, 1980·Annals of the New York Academy of Sciences·A M AttallahT J Yeatman
Oct 1, 1980·Infection and Immunity·H TsutsumiT Nakao

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Citations

Sep 1, 1985·The British Journal of Dermatology·F KanekoT Minagawa
Jun 1, 1992·Kisaengch'unghak chapchi. The Korean journal of parasitology·D K HyunK Im

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