Enhancement of Dissolution and Skin Permeability of Pentazocine by Proniosomes and Niosomal Gel

AAPS PharmSciTech
Asadullah MadniAamna Shah

Abstract

Proniosomes (PN) are the dry water-soluble carrier systems that may enhance the oral bioavailability, stability, and topical permeability of therapeutic agents. The low solubility and low oral bioavailability due to extensive first pass metabolism make Pentazocine as an ideal candidate for oral and topical sustained release delivery. The present study was aimed to formulate the PNs by quick slurry method that are converted to niosomes (liquid dispersion) by hydration, and subsequently formulated to semisolid niosomal gel. The PNs were found in spherical shape in the SEM and stable in the physicochemical and thermal analysis (FTIR, TGA, and XRD). The quick slurry method produced high recovery (> 80% yield) and better flow properties (θ = 28.1-37.4°). After hydration, the niosomes exhibited desirable entrapment efficiency (44.45-76.23%), size (4.98-21.3 μm), and zeta potential (- 9.81 to - 21.53 mV). The in vitro drug release (T100%) was extended to more than three half-lives (2-4 h) and showed good fit to Fickian diffusion indicated by Korsmeyer-Peppas model (n = 0.136-0.365 and R2 = 0.9747-0.9954). The permeation of niosomal gel was significantly enhanced across rabbit skin compared to the pure drug-derived gel. Therefore, the ...Continue Reading

References

Aug 1, 1965·Journal of Molecular Biology·A D BanghamJ C Watkins
Jul 30, 1999·International Journal of Pharmaceutics·C Hu, D G Rhodes
Jul 24, 2001·Pharmaceutical Research·A I Blazek-Welsh, D G Rhodes
Dec 14, 2001·AAPS PharmSci·A I Blazek-Welsh, D G Rhodes
Mar 17, 2004·Advanced Drug Delivery Reviews·Mark R Prausnitz
Sep 7, 2004·Journal of Materials Science. Materials in Medicine·Maria Grazia CasconeZhouhai Zhu
Jan 21, 2006·Journal of Microencapsulation·K Rama RaoM K Das
May 3, 2007·Molecular Pharmaceutics·Ankur GuptaM Balamurugan
Jan 10, 2008·AAPS PharmSciTech·Ajay B SolankiRajesh H Parikh
Jan 15, 2008·International Journal of Pharmaceutics·Donatella PaolinoMassimo Fresta
Mar 15, 2008·International Journal of Pharmaceutics·A Abd-ElbaryM I Tadros
Apr 28, 2009·International Journal of Pharmaceutics·Prabagar BalakrishnanChul Soon Yong
Jul 1, 2009·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Priya Ranjan Prasad Verma, Ashok R Chandak
May 1, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David W Deamer
May 31, 2012·AAPS PharmSciTech·Zerrin Sezgin-Bayindir, Nilufer Yuksel
Apr 13, 2013·International Journal of Pharmaceutical Investigation·Sb ShirsandD Keerthy
Dec 5, 2013·Journal of Pharmacy & Bioallied Sciences·Saurabh BansalS L Harikumar
Sep 17, 2014·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Asadullah MadniRaimar Löbenberg
May 15, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Chandra Kanti ChakrabortiPradipta Kumar Behera
Nov 18, 2015·Carbohydrate Polymers·Bushra JamilMuhammad Imran
Nov 26, 2015·Food Chemistry·Arash Abaee, Ashkan Madadlou
Feb 11, 2016·AAPS PharmSciTech·Feng Zhang, Michael A Repka
Apr 16, 2016·Journal of Liposome Research·Rawia M KhalilHadeer A El-Hashemy
Sep 8, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Muhammad Imran KhanLeena Peltonen
Nov 20, 2016·Food Chemistry·Maryam RavaghiAnna Maria Fadda

❮ Previous
Next ❯

Citations

Jan 16, 2020·Therapeutic Delivery·Swati MittalAnkit Kumar
Oct 30, 2020·International Journal of Nanomedicine·Ghada Ahmed El-EmamAbd El Gawad H Abd El Gawad
Jun 23, 2021·Journal of Pain & Palliative Care Pharmacotherapy·Apoorva Phadke, Purnima Amin
Jan 4, 2022·Pharmaceutical Development and Technology·Ahmed Al SaqrR Jayachandra Babu

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
Infrared Spectroscopy
Scanning
optical microscopy

Software Mentioned

DDsolver

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

© 2022 Meta ULC. All rights reserved