PMID: 9531989Apr 9, 1998Paper

Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells

The Journal of Antibiotics
M C RhoS Omura

Abstract

In the course of our screening for compounds that reverse multidrug resistance, we found that the cytotoxicity of vincristine was enhanced 1.5-20-fold depending on the concentration of andrastin A in vincristine-resistant KB cells (VJ-300). Andrastin A alone had no effect on the growth of drug sensitive KB cells and VJ-300 cells. On the other hand, andrastin A (25 and 50 micrograms/ml) significantly enhanced accumulation of [3H]vincristine in VJ-300 cells. Andrastin A (50 micrograms/ml) completely inhibited the binding of [3H]azidopine to the P-glycoprotein in VJ-300 cells. The result suggests that andrastin A directly interacts with P-glycoprotein and inhibits the efflux of antitumor agents in drug resistant cells.

Citations

Aug 24, 2016·Anti-cancer Drugs·Mytre Koul, Shashank Singh
Oct 28, 2017·Fungal biology and biotechnology·Sietske GrijseelsMhairi Workman
Mar 20, 2002·Folia Microbiologica·V Bĕhal
Mar 15, 2015·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Abdus-Salaam RofiatChibundu N Ezekiel
May 23, 2017·Frontiers in Microbiology·Juan F Rojas-AedoRenato Chávez
Nov 26, 2014·Journal of Applied Microbiology·R MiosoI Herrera Bravo de Laguna
Aug 25, 2016·Applied Microbiology and Biotechnology·Carlos García-Estrada, Juan-Francisco Martín
May 1, 2021·Natural Product Research·Yu-Yue QinRui-Yun Yang

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