Abstract
Immunoxel (Dzherelo) is an oral, herbal immunomodulator used in Ukraine for adjunct therapy of infectious and autoimmune diseases. Antiretroviral drug-naive, tuberculosis (TB)/HIV coinfected patients with active pulmonary TB were divided into two arms, A (n = 20) and B (n = 20), to receive first-line anti-TB therapy (ATT) or ATT + Dzherelo, respectively. As a result, three (16%) versus 12 (67%; p = 0.003) patients had Mycobacterium tuberculosis culture conversion, with time to negative culture of 6 and 4 months in arms A and B, respectively. In the ATT-alone arm, the healing of pulmonary cavitations was observed in 25% of patients at weeks 24-28, while 60% of individuals in arm B healed at 16-18 weeks (p = 0.025). The TB lesions, on chest x-ray, had cleared in 46 and 84%, with time-to-clearance of 24-28 and 16-18 weeks in arms A and B, respectively. In the ATT-alone arm, the bodyweight at baseline was 64 +/- 6.3 kg, with 13 cachexic patients who had an average weight deficit of -5.2 +/- 1.7 kg. At the end of 6 months of follow-up, they have lost an additional 0.6 kg (-5.8 +/- 2.4). The study entry-level weight in arm B was 52 +/- 5.7 kg, with 12 individuals who had a body mass deficit of -8.5 +/- 2.7 kg. The immunotherapeutic i...Continue Reading
References
Mar 18, 2000·The Journal of Infectious Diseases·L G BekkerG Kaplan
Aug 5, 2000·Phytotherapy Research : PTR·S M NewtonC W Wright
Mar 29, 2001·Public Health Nutrition·K H Lee
Nov 17, 2004·Current Pharmaceutical Design·Haruaki Tomioka
Dec 17, 2004·Journal of Medical Virology·Mireille KalouJohn N Nkengasong
Feb 18, 2005·The Journal of Infectious Diseases·Harriet Mayanja-KizzaUNKNOWN Uganda-Case Western Research Collaboration
Jun 14, 2005·International Journal of STD & AIDS·F DrobniewskiS Servetsky
Oct 4, 2005·Nature Reviews. Immunology·Paul NunnMario Raviglione
May 18, 2006·Emerging Infectious Diseases·Marieke J van der WerfLeonid V Turchenko
Nov 7, 2006·Lancet·Neel R GandhiGerald Friedland
Mar 3, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V V NikolayevskyyF A Drobniewski
Aug 24, 2007·Expert Opinion on Investigational Drugs·Jianping Liu
Apr 30, 2008·International Immunopharmacology·Lyudmila G NikolaevaGalyna A Kutsyna
Nov 26, 2008·Cytokine·Lyudmila G NikolaevaGalyna A Kutsyna
Citations
May 28, 2021·Systematic Reviews·Marcel KitengePeter S Nyasulu
Feb 22, 2012·Immunotherapy·Mercedes Gonzalez-Juarrero
Jul 14, 2012·Immunotherapy·T Mark Doherty
Dec 25, 2010·Immunotherapy·Olga V ArjanovaAldar S Bourinbaiar
Mar 10, 2012·Immunotherapy·Yuri V EfremenkoGalyna A Kutsyna
Nov 22, 2016·Immunotherapy·Uyanga BatboldAldar S Bourinbaiar