Enhancement of endothelial cell migration by constitutively active LPA(1)-expressing tumor cells

Biochemical and Biophysical Research Communications
Misaho KitayoshiToshifumi Tsujiuchi

Abstract

Lysophosphatidic acid (LPA) receptors belong to G protein-coupled transmembrane receptors (LPA receptors; LPA(1) to LPA(6)). They indicate a variety of cellular response by the interaction with LPA, including cell proliferation, migration and differentiation. Recently, we have reported that constitutive active mutated LPA(1) induced the strong biological effects of rat neuroblastoma B103 cells. In the present study, we examined the effects of mutated LPA(1) on the interaction between B103 cells and endothelial F-2 cells. Each LPA receptor expressing B103 cells were maintained in serum-free DMEM and cell motility assay was performed with a Cell Culture Insert. When F-2 cells were cultured with conditioned medium from Lpar1 and Lpar3-expressing cells, the cell motility of F-2 cells was significantly higher than control cells. Interestingly, the motile activity of F-2 cells was strongly induced by mutated LPA(1) than other cells, correlating with the expression levels of vascular endothelial growth factor (Vegf)-A and Vegf-C. Pretreatment of LPA signaling inhibitors inhibited F-2 cell motility stimulated by mutated LPA(1). These results suggest that activation of LPA signaling via mutated LPA(1) may play an important role in the p...Continue Reading

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Citations

Jul 6, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rie FukuiToshifumi Tsujiuchi
Apr 8, 2015·Biochemical and Biophysical Research Communications·Shuhei IshiiToshifumi Tsujiuchi
Aug 6, 2013·Journal of Receptor and Signal Transduction Research·Eriko TanabeToshifumi Tsujiuchi
Jan 28, 2014·Journal of Receptor and Signal Transduction Research·Toshifumi TsujiuchiNobuyuki Fukushima
Mar 21, 2013·Biochemical and Biophysical Research Communications·Ayano ShibataToshifumi Tsujiuchi
Jun 28, 2015·Molecular and Cellular Biochemistry·Shiori MoriToshifumi Tsujiuchi
Oct 9, 2012·Journal of Cellular Physiology·Filomena de NigrisClaudio Napoli
Oct 15, 2020·Biomedicines·Rohit GundamarajuSukhwinder Singh Sohal

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