Enhancement of endothelial nitric oxide production by chenodeoxycholic acids in patients with hepatobiliary diseases

Japanese Heart Journal
K ChisakiMasao Omata

Abstract

The purpose of this study was to clarify whether physiological concentrations of bile acids could affect endothelial nitric oxide production. We investigated the relationships between clinical concentrations of individual bile acids observed in patients with hepatobiliary diseases and endothelial nitric oxide production induced by each bile acid. Fifteen serum bile acids were measured using high-performance liquid chromatography combined with enzymatic fluorometry in 8 patients with liver cirrhosis, obstructive jaundice, and 8 healthy subjects. The effects of individual bile acids on nitric oxide production were examined in human umbilical endothelial cells by measuring the concentration of NO2- in the cultured medium. NO release in the blood was also determined by measuring the NO2-/NO3- concentration in these patients. In patients with hepatobiliary diseases, the plasma concentrations of chenodeoxycholic acid, ursodeoxycholic acid and cholic acid (free acid, taurine and glycine conjugates) were markedly elevated. Incubation of cells with chenodeoxycholic acid and deoxycholic acid (free acid, taurine and glycine conjugates) enhanced NO2- production in a concentration-dependent manner, while cholic acid (free and its conjugates...Continue Reading

References

Nov 1, 1977·Gut·C R PenningtonI A Bouchier
Mar 30, 1991·Lancet·P Vallance, S Moncada
Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ClàriaJ Rodés
Jan 10, 1991·Biochimica Et Biophysica Acta·C M GarnerJ M Neuberger
Jul 16, 1990·Biochemical and Biophysical Research Communications·K S WoodL J Ignarro
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R W SchrierJ Rodés
Aug 1, 1984·Clinical Science·A BomzonO S Better
Nov 1, 1982·Clinical and Experimental Pharmacology & Physiology·J P FinbergO S Better
Oct 1, 1994·Gastroenterology·M HartlebD Lebrec
Mar 17, 1997·Biochemical and Biophysical Research Communications·Y OkudaK Yamashita
Oct 6, 1997·Journal of Hepatology·M Bernardi, F Trevisani
Aug 26, 1998·The New England Journal of Medicine·P Y MartinR W Schrier

❮ Previous
Next ❯

Citations

Jun 26, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jau-Shyang HuangYann-Jia Huang
Apr 2, 2014·Journal of Clinical Biochemistry and Nutrition·Tetsuo AdachiHirokazu Hara
May 6, 2009·Molecular Carcinogenesis·Nadine VaninettiAlan G Casson
Nov 24, 2004·European Journal of Pharmacology·Ji MaToshiaki Nakajima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.