Enhancement of enrofloxacin serum antibacterial activity by calcium primed broilers

Research in Veterinary Science
R AguileraL H Sumano

Abstract

The aim of this trial was to assess the effect that calcium gluconate priming of 468 broilers has on the antibacterial activity of a standard dose of enrofloxacin. Hence, a series of oral pharmacokinetic studies were carried out in four groups of broilers medicated individually through an oral cannula as follows: group A, medicated only with enrofloxacin 10mg/kg; group B, receiving immediately one after the other, calcium gluconate (200mg/kg) and enrofloxacin 10mg/kg; group C, dosed first with calcium gluconate (200mg/kg) and 1h later enrofloxacin (10mg/kg); and group D, dosed first with calcium gluconate (200mg/kg) and 2h later enrofloxacin (10mg/kg). Broilers were bled at different times after the dose of enrofloxacin and antibacterial activity, measured as concentration of enrofloxacin, was measured by an agar diffusion assay. Results revealed that group D the greatest values of maximum serum concentration (Cs(max)), area under the concentration vs. time curve (AUC) and area under the moment curve (AUMC). These values were statistically higher than the corresponding ones derived from groups A, B and C (P<0.05). Taking Cs(max) and AUC values of group A as reference baseline, an increase of 24% and 50%, respectively, was obtai...Continue Reading

References

Aug 13, 1998·The Journal of Antimicrobial Chemotherapy·D ChattopadhyayR Bhadra
Nov 5, 1998·Bioorganic & Medicinal Chemistry·C SissiM Palumbo
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Feb 6, 2002·Trends in Microbiology·Jan MichielsJos Vanderleyden
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Jun 8, 2002·Journal of Molecular Biology·Christian G Noble, Anthony Maxwell
Dec 10, 2003·Current Opinion in Biotechnology·Christine T Barrett, John F Barrett
May 15, 2004·Poultry Science·L H SumanoM J Gracia
Jun 9, 2004·Diagnostic Microbiology and Infectious Disease·Naomi F Florea, Charles H Nightingale

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