Enhancement of epoxide hydratase activity in rat lung, kidney and liver by dietary antioxidants

Cancer Letters
R Kahl

Abstract

Enhancement of pulmonary epoxide hydratase activity in the rat was obtained by feeding a diet which contained 0.5% ethoxyquin (EQ) or 3,5-di-tert-butyl-4-hydroxytoluene (BHT). The enhancement was less marked (1.6-fold) than in the liver, where a 2-4-fold enhancement of enzyme activity was found after feeding 0.5% antioxidant. A minimal enhancing concentration of 0.1% EQ or BHT in food was established for hepatic epoxide hydratase. In kidney microsomes, elevation of enzyme activity was obtained with 0.5% EQ (1.8-fold), but not with 0.5% BHT. No concomitant increase of cytochrome P-450 content and of aryl hydrocarbon hydroxylase activity was found in the tissues studied.

References

Jan 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K AlexandrovC Frayssinet
Feb 1, 1979·Toxicology and Applied Pharmacology·R Kahl, U Wulff
Dec 14, 1978·Biochemical and Biophysical Research Communications·R KahlE Klaus
Jun 1, 1977·Toxicology and Applied Pharmacology·R Kahl, K J Netter
Jul 1, 1974·Biochemical Pharmacology·D V ParkeR Walker

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Citations

Jan 1, 1988·The International Journal of Biochemistry·G Hocman
Nov 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Y FukayamaD P Hsieh
May 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Y Fukayama, D P Hsieh
Jun 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Y Fukayama, D P Hsieh
May 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M E HernándezE Meléndez
Jan 1, 1988·Free Radical Biology & Medicine·J D Gower
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E M EllisJ D Hayes
Jul 16, 1980·Biochemical and Biophysical Research Communications·R Kahl
Oct 25, 2002·International Journal of Toxicology·Rebecca S Lanigan, Torill A Yamarik

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