Enhancement of Functionality and Therapeutic Efficacy of Cell-Based Therapy Using Mesenchymal Stem Cells for Cardiovascular Disease

International Journal of Molecular Sciences
Chul Won Yun, Sang Hun Lee

Abstract

Cardiovascular disease usually triggers coronary heart disease, stroke, and ischemic diseases, thus promoting the development of functional failure. Mesenchymal stem cells (MSCs) are cells that can be isolated from various human tissues, with multipotent and immunomodulatory characteristics to help damaged tissue repair and avoidance of immune responses. Much research has proved the feasibility, safety, and efficiency of MSC-based therapy for cardiovascular disease. Despite the fact that the precise mechanism of MSCs remains unclear, their therapeutic capability to treat ischemic diseases has been tested in phase I/II clinical trials. MSCs have the potential to become an effective therapeutic strategy for the treatment of ischemic and non-ischemic cardiovascular disorders. The molecular mechanism underlying the efficacy of MSCs in promoting engraftment and accelerating the functional recovery of injury sites is still unclear. It is hypothesized that the mechanisms of paracrine effects for the cardiac repair, optimization of the niche for cell survival, and cardiac remodeling by inflammatory control are involved in the interaction between MSCs and the damaged myocardial environment. This review focuses on recent experimental and...Continue Reading

References

May 15, 1989·Archives of Biochemistry and Biophysics·R J KellerL H Piette
Sep 1, 1996·The Annals of Thoracic Surgery·E D Verrier, E M Boyle
Nov 6, 1998·Science·J A ThomsonJ M Jones
Oct 3, 2000·The American Journal of Medicine·B P Jacobs, W S Browner
Jun 25, 2002·The Annals of Thoracic Surgery·Jay G ShakeBradley J Martin
Aug 10, 2002·Circulation Research·Kenneth R BohelerAnna M Wobus
Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·Shinya FukuharaTakeshi Nakatani
Dec 5, 2003·Journal of Molecular and Cellular Cardiology·Arnoud C FijnvandraatAntoon F M Moorman
Jul 10, 2004·Circulation Research·Mark F Pittenger, Bradley J Martin
Feb 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Paul Coats, Roger Wadsworth
Jun 2, 2005·Circulation·Douglas L Mann, Michael R Bristow
Aug 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Luciano C AmadoJoshua M Hare
Sep 15, 2005·European Journal of Heart Failure·Hainan PiaoYoung-Bae Park
Oct 4, 2005·Journal of the American College of Cardiology·Victor J DzauAlok S Pachori
Apr 4, 2006·Nature Medicine·Yoshinori MiyaharaHidezo Mori
May 11, 2006·Journal of Cell Science·Lindolfo da Silva MeirellesNance Beyer Nardi
Jul 11, 2006·Journal of Vascular Surgery·William A MarstonBlair A Keagy
Jun 8, 2007·Nature·Keisuke OkitaShinya Yamanaka
Jul 28, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Joshua W KnowlesJohn P Cooke
Aug 1, 2007·Blood·Alma J Nauta, Willem E Fibbe
Oct 24, 2007·Journal of Internal Medicine·K Le Blanc, O Ringdén
Nov 22, 2007·Science·Junying YuJames A Thomson
Mar 18, 2008·Journal of Molecular and Cellular Cardiology·Yukiko ImanishiYoshiki Sawa
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Henry C QuevedoJoshua M Hare
Feb 9, 2010·Stem Cell Research·Ruenn Chai LaiSai Kiang Lim
May 12, 2010·Immunology and Cell Biology·Sonja I BuschowWillem Stoorvogel
Jul 31, 2010·Neuron·Michael A MoskowitzCostantino Iadecola
May 24, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Anirban Sen Gupta
Jul 14, 2011·Regenerative Medicine·Ruenn Chai LaiSai Kiang Lim

❮ Previous
Next ❯

Citations

May 28, 2019·International Journal of Molecular Sciences·Loubna MaziniGabriel Malka
Oct 1, 2019·Journal of Cellular and Molecular Medicine·Felicia CarotenutoPaolo Di Nardo
Apr 21, 2020·Current Pharmaceutical Design·Guifang ZhaoWenliang Li
Sep 26, 2020·Translational Stroke Research·Meng LuSeyed Esmaeil Khoshnam
Aug 3, 2019·International Journal of Molecular Sciences·Francisco J VizosoRoman Perez-Fernandez
Sep 15, 2020·Frontiers in Bioengineering and Biotechnology·Yuting SunZhenjie Liu
Mar 16, 2021·Stem Cells and Development·Qiqi CaiWenhua Jiang
Mar 21, 2021·Journal of Tissue Engineering and Regenerative Medicine·Jin ChengDongwei Zhang
Apr 4, 2021·International Journal of Molecular Sciences·Silvia Fernández-FrancosFrancisco J Vizoso
Mar 27, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Wei LuoLing Gao

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
GTPase

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.