PMID: 9445049Jan 28, 1998Paper

Enhancement of hepatitis B virus infection by noninfectious subviral particles

Journal of Virology
M BrunsHans Will

Abstract

The biological function of the huge excess of subviral particles over virions in hepatitis B virus infections is unknown. Using the duck hepatitis B virus as a model, we unexpectedly found that subviral particles strongly enhance intracellular viral replication and gene expression. This effect is dependent on the multiplicity of infection, the ratio of virions over subviral particles, and the time point of addition of subviral particles. Most importantly, we show that the pre-S protein of the subviral particles triggers enhancement and requires the presence of the binding regions for putative cell-encoded virus receptor proteins. These data suggest that enhancement is due either to the recently described transactivation function of the pre-S protein or to signalling pathways which become activated upon binding of subviral particles to cellular receptors. The findings are of clinical importance, since they imply that infectivity of sera containing hepadnaviruses depends not only on the amount of infectious virions but also decisively on the number of particles devoid of nucleic acids. A similarly dramatic enhancing effect of noninfectious particles in other virus infections is well conceivable.

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Citations

Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L BarraudL Cova
May 13, 2003·Reviews in Medical Virology·Nir ParanYosef Shaul
Sep 19, 2007·Antimicrobial Agents and Chemotherapy·Anne Marie DoughertyAndrea Cuconati
Jun 6, 2008·Journal of Virology·Ning ChaiJohn Taylor
Sep 1, 2009·Viruses·Stephanie Schädler, Eberhard Hildt
Jul 5, 2005·Expert Opinion on Investigational Drugs·J Torresi, S A Locarnini
Nov 27, 2020·Small·Kevin BondBogdan Dragnea
Jan 12, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kotaro AokiKazuhiro Tateda
Sep 11, 1999·Journal of Virology·S TongJ R Wands
Nov 2, 1999·Virology·E MéndezC F Arias
Jul 23, 2003·Biochimica Et Biophysica Acta·Arik CooperYosef Shaul

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