PMID: 6980446Feb 1, 1982Paper

Enhancement of human B lymphocyte differentiation in vitro by thyroid hormone

Scandinavian Journal of Immunology
T Paavonen

Abstract

A study was made of the regulatory influence of a thyroid hormone, triiodothyronine (T3), on human blood T- and B-lymphocytes responses in vitro. Blood lymphocytes were stimulated with the T-cell mitogens concanavalin A (Con A) and phytohaemagglutinin (PHA), with the T-dependent B-cell activator pokeweed mitogen (PWM), and with the T-independent B-cell activator Staphylococcus aureus Cowan I bacteria in the presence of various hormone concentrations. T3 did not stimulate T-cell proliferation. The number of immunoglobulin-containing and -secreting cells (plasmablasts) was increased in PWm and Staph. aureus cultures treated with T3. The maximal enhancement was reached at a concentration of 10(-9)-10(-7) M T3. Cell fractionation techniques revealed that T3 apparently had a direct stimulatory effect on B-cell differentiation.

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Citations

Jan 1, 1986·Developmental and Comparative Immunology·S E Bachman, M M Mashaly
Jan 1, 1987·Developmental and Comparative Immunology·S E Bachman, M M Mashaly
Dec 24, 2013·The Journal of Endocrinology·Flavia Fonseca BloiseValéria de Mello-Coelho
Jul 26, 2013·Endocrine Research·Masoumeh VarediHadi Feizi
Mar 25, 2014·Fish & Shellfish Immunology·A Quesada-GarcíaJ M Navas
Dec 1, 2017·Frontiers in Immunology·Mahmood Y BilalKenneth D Beaman
Jan 4, 2003·Molecular Endocrinology·Maria NygårdMaria Bondesson
Jan 1, 1989·Archives of Gynecology and Obstetrics·R PunnonenJ Paavonen
Apr 1, 1997·The Journal of Nutrition·C CobraR D Semba
Feb 1, 1990·Journal of Endocrinological Investigation·M Provinciali, N Fabris

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